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Figure 3: A Photomicrographs of Masson's trichrome stain at × 400 for liver sections. Control groups (a and b) display fine collagen fibers (arrow) around the central vein (c) and between the hepatic cords. Sections of the toxic group showing apparent rise of collagen fibers pericentrally (star) (c), periportal (d), and extending in-between the cords of hepatocytes (arrow). Treated group (e) shows apparent improvement of the amount of collagen fibers. (f) Fibrosis score. *,#Significantly different from control, MTX, and MTX-gossypin-treated groups, respectively, at P < 0.05. MTX = methotrexate

Figure 3: A Photomicrographs of Masson's trichrome stain at × 400 for liver sections. Control groups (a and b) display fine collagen fibers (arrow) around the central vein (c) and between the hepatic cords. Sections of the toxic group showing apparent rise of collagen fibers pericentrally (star) (c), periportal (d), and extending in-between the cords of hepatocytes (arrow). Treated group (e) shows apparent improvement of the amount of collagen fibers. (f) Fibrosis score. *<sup>,#</sup>Significantly different from control, MTX, and MTX-gossypin-treated groups, respectively, at <i>P</i> < 0.05. MTX = methotrexate