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Figure 2: A picture of hepatic tissue at magnification × 400 for control rat shows normal cords of hepatocytes (arrow) around the central vein (cv) and blood sinusoids (s) (a and b). Liver tissue of toxic (c and d) and treated (e) groups showing dilated congested central and portal veins (star), inflammatory cells were observed (dashed arrows), vacuolization (oval), disorganization (i), and a binuclear hepatocyte could be seen (arrow). (f) Necro-inflammatory score. *,#Significantly different from control, MTX, and MTX-gossypin-treated groups, respectively, at P < 0.05. MTX = methotrexate

Figure 2: A picture of hepatic tissue at magnification × 400 for control rat shows normal cords of hepatocytes (arrow) around the central vein (cv) and blood sinusoids (s) (a and b). Liver tissue of toxic (c and d) and treated (e) groups showing dilated congested central and portal veins (star), inflammatory cells were observed (dashed arrows), vacuolization (oval), disorganization (i), and a binuclear hepatocyte could be seen (arrow). (f) Necro-inflammatory score. *<sup>,#</sup>Significantly different from control, MTX, and MTX-gossypin-treated groups, respectively, at <i>P</i> < 0.05. MTX = methotrexate