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Figure 1: Histopathological analysis of rat hippocampus in Pentylenetetrazole-kindling model of rats: (a) Effect of various treatments on histopathological scores of rat hippocampus – statistical analysis was done by Kruskal–Wallis test (P = 0.000) and comparison between two groups with Mann–Whitney U-test. Values are expressed as mean ± standard deviation and n = 8 for all groups. *P < 0.05 compared to saline control group, P < 0.05 compared to dimethyl sulfoxide control group, P < 0.05 compared to saline + Pentylenetetrazole group. (b) Microphotograph (×40) of rat hippocampus showing neuronal morphology: (i) saline control group showing normal neuronal cells; (ii) dimethyl sulfoxide control group showing some damage in neuronal cells; (iii) Pentylenetetrazole group showing diffuse neuronal injury of the cells, and (iv) dimethyl sulfoxide + Pentylenetetrazole group showing diffuse neuronal injury of the cells. Arrow – densely stained nuclei of neurons indicating chromatin clumping

Figure 1: Histopathological analysis of rat hippocampus in Pentylenetetrazole-kindling model of rats: (a) Effect of various treatments on histopathological scores of rat hippocampus – statistical analysis was done by Kruskal–Wallis test (<i>P</i> = 0.000) and comparison between two groups with Mann–Whitney U-test. Values are expressed as mean ± standard deviation and <i>n</i> = 8 for all groups. *<i>P</i> < 0.05 compared to saline control group, <sup>†</sup><i>P</i> < 0.05 compared to dimethyl sulfoxide control group, <sup>‡</sup><i>P</i> < 0.05 compared to saline + Pentylenetetrazole group. (b) Microphotograph (×40) of rat hippocampus showing neuronal morphology: (i) saline control group showing normal neuronal cells; (ii) dimethyl sulfoxide control group showing some damage in neuronal cells; (iii) Pentylenetetrazole group showing diffuse neuronal injury of the cells, and (iv) dimethyl sulfoxide + Pentylenetetrazole group showing diffuse neuronal injury of the cells. Arrow – densely stained nuclei of neurons indicating chromatin clumping