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Figure 3: Effect of metabolic syndrome on hippocampal cytokine profile. (a) Metabolic syndrome led in a significant increase in hippocampal tumor necrosis factor-α levels compared to control. While treatment with minocycline partially reversed metabolic syndrome-associated increase in hippocampal tumor necrosis factor-α. (b) Metabolic syndrome led in significant increase in hippocampal Interleukin-1 β levels compared to control. While treatment with minocycline partially reversed metabolic syndrome-associated increase in hippocampal interleukin-1 β levels. ***P < 0.001, **P < 0.01 all values are expressed as mean ± standard error of the mean for n = 10

Figure 3: Effect of metabolic syndrome on hippocampal cytokine profile. (a) Metabolic syndrome led in a significant increase in hippocampal tumor necrosis factor-α levels compared to control. While treatment with minocycline partially reversed metabolic syndrome-associated increase in hippocampal tumor necrosis factor-α. (b) Metabolic syndrome led in significant increase in hippocampal Interleukin-1 β levels compared to control. While treatment with minocycline partially reversed metabolic syndrome-associated increase in hippocampal interleukin-1 β levels. ***<i>P</i> < 0.001, **<i>P</i> < 0.01 all values are expressed as mean ± standard error of the mean for <i>n</i> = 10