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Figure 3: Telmisartan and esculetin combination alleviated histone posttranslational modifications – H3K9 me2, H3K9Ac, H2AK119Ub, and H2BK120Ub in type 2 diabetic heart Immunoblotting in total heart from all groups for PTHMs-H3K9 me2 (panel a), H3K9Ac (panel b), H2AK119Ub (panel c), and H2BK120Ub (panel d) were performed and a representative of three different blots were shown in (A); Proteins level were quantified by scanning densitometry using Image J software (B) Each data point is represented as mean ± standard error of mean, n = 3 blots/protein *P < 0.05 versus NC; #P < 0.05 versus T2DC; $P < 0.05 versus T2DC+E; @P < 0.05 versus T2DC+T

Figure 3: Telmisartan and esculetin combination alleviated histone posttranslational modifications – H3K9 me2, H3K9Ac, H2AK119Ub, and H2BK120Ub in type 2 diabetic heart Immunoblotting in total heart from all groups for PTHMs-H3K9 me2 (panel a), H3K9Ac (panel b), H2AK119Ub (panel c), and H2BK120Ub (panel d) were performed and a representative of three different blots were shown in (A); Proteins level were quantified by scanning densitometry using Image J software (B) Each data point is represented as mean ± standard error of mean, <i>n</i> = 3 blots/protein *<i>P</i> < 0.05 versus NC; <sup>#</sup><i>P</i> < 0.05 versus T2DC; <sup>$</sup><i>P</i> < 0.05 versus T2DC+E; <sup>@</sup><i>P</i> < 0.05 versus T2DC+T