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Figure 1: Telmisartan and esculetin combination attenuated increased expression of Keap1 and fibronectin in type 2 diabetic heart. (a) H and E staining , (b) the immunostaining of Keap1, and (c) fibronectin in heart sections, and their respective bar graph for % nuclei positive area, % Keap1 positive area, and % fibronectin positive area calculated semiquantitatively using ImageJ software. All values are represented as means ± standard error of mean from at least 25 sections per group. The scale bar represents 50 μm (original magnification, ×100). Note: Each data is represented as means ± standard error of mean (n = 6). *P < 0.05 versus NC; #P < 0.05 versus T2DC; $P < 0.05 versus T2DC+E; @P < 0.05 versus T2DC +T

Figure 1: Telmisartan and esculetin combination attenuated increased expression of Keap1 and fibronectin in type 2 diabetic heart. (a) H and E staining , (b) the immunostaining of Keap1, and (c) fibronectin in heart sections, and their respective bar graph for % nuclei positive area, % Keap1 positive area, and % fibronectin positive area calculated semiquantitatively using ImageJ software. All values are represented as means ± standard error of mean from at least 25 sections per group. The scale bar represents 50 μm (original magnification, ×100). Note: Each data is represented as means ± standard error of mean (<i>n</i> = 6). *<i>P</i> < 0.05 versus NC; <sup>#</sup><i>P</i> < 0.05 versus T2DC; <sup>$</sup><i>P</i> < 0.05 versus T2DC+E; <sup>@</sup><i>P</i> < 0.05 versus T2DC +T