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Figure 2: Representative section of colonic tissue stained with hematoxylin and eosin. Light micrograph of vehicle control mice shows normal architecture; 2,4,6-trinitrobenzenesulfonic acid-control group show destruction of epithelial architecture with loss of epithelial integrity, edema, and intense cellular infiltration; sulfasalazine shows intact epithelial cell, mild edema, and necrosis; Karanjin (100 mg/kg) + 2,4,6-trinitrobenzenesulfonic acid shows less epithelial infiltration, no edema, and necrosis; Karanjin (200 mg/kg) + 2,4,6-trinitrobenzenesulfonic acid shows marked restoration of normal epithelial structure

Figure 2: Representative section of colonic tissue stained with hematoxylin and eosin. Light micrograph of vehicle control mice shows normal architecture; 2,4,6-trinitrobenzenesulfonic acid-control group show destruction of epithelial architecture with loss of epithelial integrity, edema, and intense cellular infiltration; sulfasalazine shows intact epithelial cell, mild edema, and necrosis; Karanjin (100 mg/kg) + 2,4,6-trinitrobenzenesulfonic acid shows less epithelial infiltration, no edema, and necrosis; Karanjin (200 mg/kg) + 2,4,6-trinitrobenzenesulfonic acid shows marked restoration of normal epithelial structure