Indian J Pharm Close
 

Figure 4: Schematic depiction of dissolving microneedles in which drug is embedded in the matrix of dissolving microneedles. (a) Hydroscopic lyophilized drug reservoir accelerates uptake of skin interstial fluid into hydrogel-forming microneedles, where drug release into skin from the swell; (b) lyophilized drug reservoir dissolves, maximizing drug release; (c) microneedles are removed completely intact from skin, leaving no polymer behind

Figure 4: Schematic depiction of dissolving microneedles in which drug is embedded in the matrix of dissolving microneedles. (a) Hydroscopic lyophilized drug reservoir accelerates uptake of skin interstial fluid into hydrogel-forming microneedles, where drug release into skin from the swell; (b) lyophilized drug reservoir dissolves, maximizing drug release; (c) microneedles are removed completely intact from skin, leaving no polymer behind