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Figure 1: Antinociceptive effect evaluated by the hot plate test. (a) Please note the variability of basal latency period and hence these values were not considered in the experimental results (b) % maximum possible effect shows rapid development of tolerance after morphine treatment. However, co-administration of fosaprepitant with morphine increased the antinociceptive effect of morphine (days 1.4) and also attenuated tolerance (days 1 and 3). Values are represented as mean ± standard error of mean Ф P < 0.05, ** P < 0.01, ***,≠≠≠ P < 0.001

Figure 1: Antinociceptive effect evaluated by the hot plate test. (a) Please note the variability of basal latency period and hence these values were not considered in the experimental results (b) % maximum possible effect shows rapid development of tolerance after morphine treatment. However, co-administration of fosaprepitant with morphine increased the antinociceptive effect of morphine (days 1.4) and also attenuated tolerance (days 1 and 3). Values are represented as mean ± standard error of mean Ф <i>P</i> < 0.05, ** <i>P</i> < 0.01, ***,≠≠≠ <i>P</i> < 0.001