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Figure 1: Chemical structures of xanthone derivatives HBK-5 (a), HBK-8 (b), HBK-9 (c), HBK-12 (d). HBK-5: 3-chloro-5-[(4-methylpiperazin-1-yl)methyl]-9H-xanthen-9-one; HBK-8: 6-methoxy-2-[(4-methylpiperazin-1-yl) methyl]-9H-xanthen-9-one dihydrochloride; HBK-9: 2-[(4-benzylpiperazin-1-yl) methyl]-6-methoxy-9H-xanthen-9-one dihydrochloride; HBK-12: 2-{[4-(2-methoxyphenyl) piperazin-1-yl] methyl}-9H-xanthen-9-one hydrochloride

Figure 1: Chemical structures of xanthone derivatives HBK-5 (a), HBK-8 (b), HBK-9 (c), HBK-12 (d). HBK-5: 3-chloro-5-[(4-methylpiperazin-1-yl)methyl]-9H-xanthen-9-one; HBK-8: 6-methoxy-2-[(4-methylpiperazin-1-yl) methyl]-9H-xanthen-9-one dihydrochloride; HBK-9: 2-[(4-benzylpiperazin-1-yl) methyl]-6-methoxy-9H-xanthen-9-one dihydrochloride; HBK-12: 2-{[4-(2-methoxyphenyl) piperazin-1-yl] methyl}-9H-xanthen-9-one hydrochloride