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Figure 1: Orexin A antagonist (SB-334867) in the nucleus accumbens. Bars represent, (a) water and (b) food intake of rats injected with SB-334867 in the nucleus accumbens, at 1st, 2nd, 4th and 24 h time period with dose of 0 (0.9% saline = Group 1) and 3 ng SB-334867 (Group 2) or 6 ng SB-334867 (Group 3), each bar represents the mean ± standard error of mean, (*) indicates significant difference between Group 1 versus Group 2 or Group 3, (#) indicates, significant difference between Group 2 versus Group 3. Analysis by ANOVA significance (post hoc Tukey highly significant difference, n = 18), 1st h food: Group 1 versus Group 3** P < 0.002, 24 h food: Group 1 versus Group 3** P < 0.028; Group 2 versus Group 3 #P < 0.05, 24 h water: Group 1 versus Group 3** P < 0.002; Group 2 versus Group 3 ##P < 0.006

Figure 1: Orexin A antagonist (SB-334867) in the nucleus accumbens. Bars represent, (a) water and (b) food intake of rats injected with SB-334867 in the nucleus accumbens, at 1st, 2nd, 4th and 24 h time period with dose of 0 (0.9% saline = Group 1) and 3 ng SB-334867 (Group 2) or 6 ng SB-334867 (Group 3), each bar represents the mean ± standard error of mean, (*) indicates significant difference between Group 1 versus Group 2 or Group 3, (#) indicates, significant difference between Group 2 versus Group 3. Analysis by ANOVA significance (<i>post hoc</i> Tukey highly significant difference, <i>n</i> = 18), 1st h food: Group 1 versus Group 3** <i>P</i> < 0.002, 24 h food: Group 1 versus Group 3** <i>P</i> < 0.028; Group 2 versus Group 3 #<i>P</i> < 0.05, 24 h water: Group 1 versus Group 3** <i>P</i> < 0.002; Group 2 versus Group 3 ##<i>P</i> < 0.006