Figure 2: Glomerular morphology in various groups (PAS-stained, 400 X). (a) represented a sham operated animal and shows normal glomeruli. Vehicle control (b) and aliskiren (ASK) treated (c) glomeruli showing moderate to severe grades of glomerulosclerosis with obliteration of glomerular space and thickening of basement membrane marked by arrow. 5/6 NPX kidney glomeruli from pentoxifylline (PTX) (d); Combination of ASK + PTX (e) treated groups represented minimal grade of glomerulosclerosis