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Figure 4: Regulation of serotonin synthesis by brain leptin levels. Excessive brain leptin levels directly inhibit tryptophan hydroxylase-2 thereby decreasing the circulating neuronal levels of serotonin (5-hydroxytryptamine)[41]

Figure 4: Regulation of serotonin synthesis by brain leptin levels. Excessive brain leptin levels directly inhibit tryptophan hydroxylase-2 thereby decreasing the circulating neuronal levels of serotonin (5-hydroxytryptamine)<sup>[41]</sup>