Figure 1: Possible diabetic factors that can contribute to depression in diabetic individuals. BDNF=Brain-derived neurotrophic factor, MAO=Monoamine oxidase, HPA=Hypothalamic-pituitary-adrenal axis, serotonin transporter gene 5' promoter region, DG=Dentate gyrus, GSK3-β=Glycogen synthase kinase 3 β, IRS=Insulin receptor substrate