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Figure 5: Effect of FFALF on histopathology of skin tissue in mice at the end of 16th week. (a) Vehicle control, (b) FFALF-5mg/kg only, (c) Carcinogenic Control, (d) FFALF-5 mg/kg + DMBA, (e) FFALF-10 mg/kg + DMBA and (f) FFALF- 20 mg/kg + DMBA. After termination of 16th week, the skin samples obtained from dissection were fixed in 10% formalin. Stained with haematoxylin and eosin and observed by Nikon Eclipse E-200 Photomicrographic system (400x). Arrows shaped hyperplasia of epidermis (black), keratinized pearls (yellow), premalignant lesions at basement membrane (red) and rete ridges (blue)

Figure 5: Effect of FFALF on histopathology of skin tissue in mice at the end of 16th week. (a) Vehicle control, (b) FFALF-5mg/kg only, (c) Carcinogenic Control, (d) FFALF-5 mg/kg + DMBA, (e) FFALF-10 mg/kg + DMBA and (f) FFALF- 20 mg/kg + DMBA. After termination of 16<sup>th</sup> week, the skin samples obtained from dissection were fixed in 10% formalin. Stained with haematoxylin and eosin and observed by Nikon Eclipse E-200 Photomicrographic system (400x). Arrows shaped hyperplasia of epidermis (black), keratinized pearls (yellow), premalignant lesions at basement membrane (red) and rete ridges (blue)