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Figure 4: Peripheral antinociceptive effects of co-administration of ellagic acid (EA) with sildenafil (Sil) on the second phase of formalin test. The rats were pretreated with combination of inactive doses of EA (60 mcg/paw) and Sil (25 or 50 mcg/paw) 20 min before formalin injection (50 ìl, 2.5%) into the right (ipsilateral, IL) or left (contralateral, CL) hind paw. The cumulative numbers of paw flinching were determined at 15– 60 min after formalin. Data are expressed as mean ± S.E.M. (n = 8). *P < 0.05 vs. vehicle (VEH) group. #P < 0.05 vs. either drug alone (one-way ANOVA wirh Dunnettæs test)

Figure 4: Peripheral antinociceptive effects of co-administration of ellagic acid (EA) with sildenafil (Sil) on the second phase of formalin test. The rats were pretreated with combination of inactive doses of EA (60 mcg/paw) and Sil (25 or 50 mcg/paw) 20 min before formalin injection (50 ìl, 2.5%) into the right (ipsilateral, IL) or left (contralateral, CL) hind paw. The cumulative numbers of paw flinching were determined at 15– 60 min after formalin. Data are expressed as mean ± S.E.M. (<i>n</i> = 8). *<i>P</i> < 0.05 vs. vehicle (VEH) group. #<i>P</i> < 0.05 vs. either drug alone (one-way ANOVA wirh Dunnettæs test)