Indian J Pharm Close
 

Figure 3: Peripheral antinociceptive effects of co-administration of ellagic acid (EA) with sildenafil (Sil) on the first phase of formalin test in rats. The animals were pretreated with sub-effective dose of EA (60 mcg/paw) or vehicle (VEH) and inactive doses of Sil (25 or 50 mcg/paw) 20 min before formalin injection into the right (ipsilateral, IL) or left (contralateral, CL) hind paw. All data are expressed as mean ± S.E.M. (n = 8). *P < 0.05 compared with vehicle group. #P < 0.05 compared with either drug alone (one-way ANOVA with Dunnettæs test)

Figure 3: Peripheral antinociceptive effects of co-administration of ellagic acid (EA) with sildenafil (Sil) on the first phase of formalin test in rats. The animals were pretreated with sub-effective dose of EA (60 mcg/paw) or vehicle (VEH) and inactive doses of Sil (25 or 50 mcg/paw) 20 min before formalin injection into the right (ipsilateral, IL) or left (contralateral, CL) hind paw. All data are expressed as mean ± S.E.M. (<i>n</i> = 8). *<i>P</i> < 0.05 compared with vehicle group. #<i>P</i> < 0.05 compared with either drug alone (one-way ANOVA with Dunnettæs test)