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Figure 1: (a) Valproic acid (VPA) and ammonia levels as a function of time (days). Vertical axes: Straight line (left): VPA levels; dashed line (right): Venous ammonia levels. Day 1 indicates the day in which the patient overdosed herself. (b) Logarithm of normalized VPA and ammonia levels as a function of time in days. The normalization for each compound, for levels at each recorded time point (x) was to its recorded maximum level (xmax). The normalized log-linear plot of VPA showed linear fi rst-order decay kinetics with a calculated t½ = 15.08 h (R² = 0.994)

Figure 1: (a) Valproic acid (VPA) and ammonia levels as a function of time (days). Vertical axes: Straight line (left): VPA levels; dashed line (right): Venous ammonia levels. Day 1 indicates the day in which the patient overdosed herself. (b) Logarithm of normalized VPA and ammonia levels as a function of time in days. The normalization for each compound, for levels at each recorded time point (x) was to its recorded maximum level (xmax). The normalized log-linear plot of VPA showed linear fi rst-order decay kinetics with a calculated t½ = 15.08 h (R² = 0.994)