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Figure 1: Histology of kidney after 6-days study period. H and E, ×20 of kidney sections in fi ve different groups of animals revealing signifi cantly higher degree of brush border in renal tubules (red arrowheads) and glomerulus (red asterisk). Cast formation (yellow asterisk), tubular necrosis (yellow arrow heads), and cell detachment (orange arrows) have seen in GM-treated group. Further damage in all treated groups compared with group II shows remarkable improvement after E. ganitrus and MP treatment. H and E = hematoxylin and eosin. a = Group I(CMC), b = Group II(GM 100 mg/kg), c = Group III (GM+EM 100 mg/kg), d = Group IV (GM+EG 200 mg/kg), e=Group V (GM+EM 400 mg/kg), f = Group VI (GM+MP 12.5 mg/kg)

Figure 1: Histology of kidney after 6-days study period. H and E, ×20 of kidney sections in fi ve different groups of animals revealing signifi cantly higher degree of brush border in renal tubules (red arrowheads) and glomerulus (red asterisk). Cast formation (yellow asterisk), tubular necrosis (yellow arrow heads), and cell detachment (orange arrows) have seen in GM-treated group. Further damage in all treated groups compared with group II shows remarkable improvement after E. ganitrus and MP treatment. H and E = hematoxylin and eosin. a = Group I(CMC), b = Group II(GM 100 mg/kg), c = Group III (GM+EM 100 mg/kg), d = Group IV (GM+EG 200 mg/kg), e=Group V (GM+EM 400 mg/kg), f = Group VI (GM+MP 12.5 mg/kg)