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Figure 2: Expressions of Smad3 (A1-3), TGF-β1 (B1-3), α-SMA (C1-3), TIMP-1 (D1-3) in liver tissue (×200). Lane 1, rats in control group; Lane 2: rats in the treatment group (Huisheng oral solution); Lane 3: rats in model group (normal saline+CCl4). Considerable expression of Smad3 protein was observed among the periportal fibrotic areas, central vein, and fibrous septa in model group (A3) compared with normal group (A1). Huisheng oral solution treatment reduced the expression of Smad3 compared with the model group (A2). The expression of TGF-β1, α-SMA and TIMP-1 was consistent with Smad3

Figure 2: Expressions of Smad3 (A1-3), TGF-β1 (B1-3), α-SMA (C1-3), TIMP-1 (D1-3) in liver tissue (×200). Lane 1, rats in control group; Lane 2: rats in the treatment group (Huisheng oral solution); Lane 3: rats in model group (normal saline+CCl4). Considerable expression of Smad3 protein was observed among the periportal fibrotic areas, central vein, and fibrous septa in model group (A3) compared with normal group (A1). Huisheng oral solution treatment reduced the expression of Smad3 compared with the model group (A2). The expression of TGF-β1, α-SMA and TIMP-1 was consistent with Smad3