Figure 1: (a) chromatogram obtained from the plasma extract of the patient's mother :undetectable UH2 was observed and a very high accumulation of U was detected suggesting that the subject was profoundly DPD deficient (direct ultraviolet detection at 205 nm) (b) chromatogram obtained from the plasma extract of the patient's father. The two metabolites were detected (direct ultraviolet detection at 205 nm). The UH2 peak was higher than the U peak suggesting a normal UH2/U plasmatic ratio