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Figure 4: Light microscopy of renal tissue from rats injecting (a) control, (b) cisplatin (CP) alone, (c) pre-treatment with HSME 250 and CP, (d) pre-treatment with HSME 500 and CP, (e) pre-treatment with silymarin and CP (H and E, ×10 (a) Renal tubules are normal. (b) Tubules show severe (+++) necrosis. (c) Tubules show necrosis and slight degenerative changes (++). (d) Tubules show necrosis and slight degenerative changes (+). (e) Tubules show slight necrosis and no degenerative changes (+)

Figure 4: Light microscopy of renal tissue from rats injecting (a) control, (b) cisplatin (CP) alone, (c) pre-treatment with HSME 250 and CP, (d) pre-treatment with HSME 500 and CP, (e) pre-treatment with silymarin and CP (H and E, ×10 (a) Renal tubules are normal. (b) Tubules show severe (+++) necrosis. (c) Tubules show necrosis and slight degenerative changes (++). (d) Tubules show necrosis and slight degenerative changes (+). (e) Tubules show slight necrosis and no degenerative changes (+)