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Figure 2: Effect of HAE (10– 100 mg/kg), EAE (10– 100 mg/kg), PEE (10– 100 mg/kg) and morphine (0.3-3 mg/kg) on the time course curves (a, c, e) and the total nociceptive score (calc. as AUCs) (b, d, f) of formalin-induced nociception in mice. Nociceptive scores are shown in 5-minute time blocks up to 60 min for the time course curves. Data are presented as mean ± SEM (n = 5). *P < 0.05, **P < 0.01, ***P < 0.001 compared to the control group (ctrl) (two-way repeated measures ANOVA followed by Bonferroni's post hoc). P < 0.05, ††P < 0.01, †††P < 0.001 compared to the control group (ctrl) (one-way ANOVA followed by Newman– Keuls post hoc)

Figure 2: Effect of HAE (10– 100 mg/kg), EAE (10– 100 mg/kg), PEE (10– 100 mg/kg) and morphine (0.3-3 mg/kg) on the time course curves (a, c, e) and the total nociceptive score (calc. as AUCs) (b, d, f) of formalin-induced nociception in mice. Nociceptive scores are shown in 5-minute time blocks up to 60 min for the time course curves. Data are presented as mean ± SEM (<i>n</i> = 5). *<i>P</i> < 0.05, **<i>P</i> < 0.01, ***<i>P</i> < 0.001 compared to the control group (ctrl) (two-way repeated measures ANOVA followed by Bonferroni's <i>post hoc</i>). <sup>†</sup><i>P</i> < 0.05, <sup>††</sup><i>P</i> < 0.01, <sup>†††</sup><i>P</i> < 0.001 compared to the control group (ctrl) (one-way ANOVA followed by Newman– Keuls <i>post hoc</i>)