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Figure 5: Antidiarrheal effi cacy of DQA in human intestinal T84 cells and mouse closed-loop model of cholera. (a) Inhibitory effect of DQA on cholera toxin-induced active chloride secretion across T84 cell monolayer. Inset shows a time tracing of cholera toxin-induced short-circuit current of control (no DQA). (b) In vivo effi cacy of DQA in murine closed-loop model of cholera toxin-induced intestinal fl uid secretion. (Left) Photograph of isolated mouse midjejunal loops at 4 h after luminal injection of cholera toxin (1 μg), cholera toxin (1 μg) plus DQA and saline control. (Right) Summary of loop weight/length ratios. Data are expressed as mean ± S.E.; n = 5; P < 0.05. (c) Effect of DQA on intestinal fl uid absorption in murine closed-loop model. Data shown are mean ± S.E.; n = 3

Figure 5: Antidiarrheal effi cacy of DQA in human intestinal T84 cells and mouse closed-loop model of cholera. (a) Inhibitory effect of DQA on cholera toxin-induced active chloride secretion across T84 cell monolayer. Inset shows a time tracing of cholera toxin-induced short-circuit current of control (no DQA). (b) In vivo effi cacy of DQA in murine closed-loop model of cholera toxin-induced intestinal fl uid secretion. (Left) Photograph of isolated mouse midjejunal loops at 4 h after luminal injection of cholera toxin (1 μg), cholera toxin (1 μg) plus DQA and saline control. (Right) Summary of loop weight/length ratios. Data are expressed as mean ± S.E.; n = 5; P < 0.05. (c) Effect of DQA on intestinal fl uid absorption in murine closed-loop model. Data shown are mean ± S.E.; n = 3