Figure 1: Absorbance changes at 608 nm (a) and turbidity measurements at 400 nm (b) of the interaction of various concentrations of mitoxantrone with hepatocytes nuclei (.) and soluble chromatin (.). Interaction was carried out at 23 °C for 40 min in 0.25 M sucrose, 25 mM NaCl and 10 mM Tris--HCl, pH 7.4 (n=4).