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Figure 1 :Effect of i.c.v. injection of histamine on the numbers of writhes induced by acetic acid in rats. Each column represents mean ± SEM (n = 6 rats for normal saline, six rats for histamine 2.5 and 10 μg, and six rats for histamine 40 μg), *P < 0.05 vs. normal saline and histamine (2.5 μg), †P < 0.05 vs. histamine at the dose of 10 μg (one-way ANOVA followed by Duncan's test), i.c.v.: intracerebroventricular.

Figure 1 :Effect of i.c.v. injection of histamine on the numbers of writhes induced by acetic acid in rats. Each column represents mean ± SEM (n = 6 rats for normal saline, six rats for histamine 2.5 and 10 μg, and six rats for histamine 40 μg), *P < 0.05 vs. normal saline and histamine (2.5 μg), †P < 0.05 vs. histamine at the dose of 10 μg (one-way ANOVA followed by Duncan's test), i.c.v.: intracerebroventricular.