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Figure 1 :(A) Competitive nature of sitagliptin. IC50s determined at different substrate concentrations using 10 ng human recombinant DPP-IV enzyme plotted against increasing substrate concentrations. The values represent the mean ± S.E.M (n=3); (B) Tight binding nature of sitagliptin. IC50s determined at different human plasma volume plotted against increasing plasma volume (DPP-IV source). The values represent the mean ± S.E.M (n=3).

Figure 1 :(A) Competitive nature of sitagliptin. IC50s determined at different substrate concentrations using 10 ng human recombinant DPP-IV enzyme plotted against increasing substrate concentrations. The values represent the mean ± S.E.M (n=3); (B) Tight binding nature of sitagliptin. IC50s determined at different human plasma volume plotted against increasing plasma volume (DPP-IV source). The values represent the mean ± S.E.M (n=3).