IPSIndian Journal of Pharmacology
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   1990| July-September  | Volume 22 | Issue 3  
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Effect of Piper betle Linn (Stalk) extract on male rat fertility
P Adhikary, J Banerji, D Choudhuri, AK Das, CC Deb, SR Mukherjee, A Chatterjee
July-September 1990, 22(3):145-149
1. Chronic oral administration of the crude alcoholic extract of the stalk of the leaf of Piper betle Linn. showed antifertility effect. This was manifested by the antiandrogenic action in male rats. 2. Noticeable decrease in relative organ weights with 0-33% fertility rate, reduced sperm count and sluggish motility at doses of 1.25 and 1.5 g/kg daily for 30 consecutive days were recorded. 3. Significant increase (P<0.0l) in cholesterol (adrenal and testis) was an important manifestation. 4. It could be concluded that the plausible cause of infertility in male rats was due to inhibition of steroidogenesis.
[ABSTRACT]   Full text not available  [PDF]
  2,653 402 -
Simultaneous HPLC measurements of phenobarbitone. phenytoin and carbamazepine from plasma samples
MV Joshi, SM Pohujani, NA Kshirsagar, PH Shah, VN Acharya
July-September 1990, 22(3):177-179
1. A specific and sensitive HPLC method for simultaneously quantitating phenobarbitone, pheoytoin and carbamazepine is described. The sensitivity of the method was 0.1 'g/ml for all the three drugs. The method compared well with EMIT assay (syva kits)
[ABSTRACT]   Full text not available  [PDF]
  2,215 364 -
Acute toxicity with lethal dose of methaquolone and diphenhydramine combination (mandrax) in humans
TVS Arya, SP Singh, VK Kulshrestha, RC Arora
July-September 1990, 22(3):165-167
Full text not available  [PDF]
  2,226 125 -
Hypoglycaemic activity of leaves of Lagerstroemia speciosa (L) pers
Y Mishra, MSY Khan, R Zafar, SS Agarwal
July-September 1990, 22(3):174-176
Full text not available  [PDF]
  1,797 260 -
Rational use of topical corticosteroids in dermatology
SC Sharma, R Uppal, PL Sharma, S Kaur
July-September 1990, 22(3):141-144
1. One thousand and eighty prescriptions of dermatology patients were analysed regarding potency of topical corticosteroids, frequency, duration, site of application and the quantity used. 2. Potent topical corticosteroids were prescribed for 41% and very potent formulations for 22% patients. 3. Frequency of application was mentioned in most (93%) of prescriptions but quantity to be used in only 12% prescriptions.
[ABSTRACT]   Full text not available  [PDF]
  1,668 316 -
Mechanism of action of various inotropic agents : A search for a digitals substitute
BH Vasavada, AA Mehta, DD Santani, RK Goyal
July-September 1990, 22(3):119-127
Full text not available  [PDF]
  1,543 171 -
Ampicillin and amoxycillin induced adverse drug reaction profile
Verma Kamini, KC Singhal, S Kumar
July-September 1990, 22(3):155-161
Full text not available  [PDF]
  1,357 210 -
Busulfan induced changes in lens nucleic acids
Cherian Mary, UM Rawal
July-September 1990, 22(3):150-154
1. The levels of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) in the lens of control as well as Busulfan treated rats were determined. 2. The treated, non-cataractous lenses showed an increase in the DNA and RNA levels while the cataractous lenses showed decrease. 3. These changes in the nucleic acids were reflected on the protein synthesis, which was observed to increase prior to cataract formation and decrease during the progression of cataract. 4. These findings of the action of Busulfan in the above parameters have been correlated in the following ways : (1) the defense mechanism is evoked prior to cataract formation thus maintaining the lens transparency for a while (2) the cumulative action of the drug could produce a gradual inhibitory action on the nucleic acids thereby inhibiting protein synthesis and impairing the enzyme systems involved in the defense mechanism of the lens. 5. This could lead to cataractous changes in the busulfan treated lenses.
[ABSTRACT]   Full text not available  [PDF]
  1,250 91 -
Platelet factor-3 and its modification by aspirin
Jha Sanjeev, Chandra Mahesh, Kumar Arvind
July-September 1990, 22(3):138-140
1. This study was carried out on 40 healthy male subjects administered aspirin orally in dosages of 75, 150, 300 and 600 mg once only and their Platelet Factor-3 (PF3) release time was determined. 2. All doses of aspirin caused a significant inhibition of PF3 release which usually lasted for 3 days. 3. 600 mg of Aspirin was observed to exert maximal effect on PF3 release.
[ABSTRACT]   Full text not available  [PDF]
  1,229 98 -
Alteration in the levels of rifampicin in pleural fluid following simultaneous administration of prednisolone in patients of tubercular pleural effusion
AR Wagay, KC Singhal, Malik Abida, R Bhargava
July-September 1990, 22(3):133-137
Full text not available  [PDF]
  1,090 83 -
Some pharmacological studies on Taurine
VM Gandhi, MJ Mulky
July-September 1990, 22(3):128-132
Full text not available  [PDF]
  1,048 119 -
Pharmacokinetics of sulfadimidine in calves
SK Garg, SK Rastogi, C Varshneya
July-September 1990, 22(3):162-164
Full text not available  [PDF]
  1,023 111 -
Effect of toxic extract of Barium methacrylate (monomer) on mesenteric mast cells of chicken
K Rathinam, PV Mohanan, Michael Lizzy
July-September 1990, 22(3):182-183
Full text not available  [PDF]
  1,043 80 -
Characterization of adrenoceptors mediating plasma fibrinolysis
S Lata, VK Srivastava, RS Saxena, A Kumar, RK Srivastava, KK Saxena
July-September 1990, 22(3):168-170
Full text not available  [PDF]
  1,015 72 -
Seizures after administration of intravenous lignocaine for ventricular arrhythmia in a patient of acute myocardial Infarction
Kandpal Sangeeta, KC Garg
July-September 1990, 22(3):180-181
Full text not available  [PDF]
  983 80 -
Cardiac component in nitroxazepine induced hypotension in mammals
ND Balani, AG Shembekar, MK Jagtap
July-September 1990, 22(3):171-173
Full text not available  [PDF]
  970 73 -
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