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   1990| April-June  | Volume 22 | Issue 2  
 
 
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RESEARCH PAPER
Double blind study to assess the efficacy of Septilin in acute rhinitis
SC Sharma, Bhargava Rakesh, KC Singhal
April-June 1990, 22(2):103-106
1. A double blind non crossover, placebo-controlled trial was done to assess the efficacy of Septilin, an Ayurvedic preparation, in comparison with chlorpheniramine maleate (CPM). 2. Group 1 (n=lOO) was administered Septilin 2 tabs t. i. d. with a placebo of CPM and Group II (n =90) was administered CPM (25 mg) t. i. d. with a placebo of Septilin. 3. Based on clinical assessment and patients self assessment score the two treatments brought about relief to the same extent. Septilin in a dose of 2 tabs t. i. d. was well tolerated.
[ABSTRACT]   Full text not available  [PDF]
  2,203 143 -
RESEARCH PAPER
Metoprolol & Pindolol : A comparative study in essential hypertension
Razdan Gugli, Jeelani Zubaida
April-June 1990, 22(2):85-88
1. The antihypertensive effect of metoprolol and pindolol were compared in 10 young and middle aged patients of essential hypertension. 2. Patients received blind placebo therapy two weeks before the trial commenced. 3. Two groups of patients were randomely assigned to metoprolol (50 mg) 0 D. and pindolol (5 mg) B. D. treatments respectively and then crossed over for comparative evaluation for a total period of eight weeks. 4. Both treatments significantly reduced lying and standing, systolic and diastolic blood pressures as compared to placebo. 5. Comparing the treatments between zero to eight weeks in both groups, fall in blood pressure was highly significant in patients receiving pindolol in comparison to patients receiving metoprolol. 6. Blood pressure was better sustained and side-effects were less with pindolol than with metoprolol.
[ABSTRACT]   Full text not available  [PDF]
  1,789 164 -
Comparative bioavailability of three paracetamol preparations
GK Patnaik, MUR Naidu, Sekhar K Ravi, VS Saxena, Datla Renuka
April-June 1990, 22(2):89-91
Full text not available  [PDF]
  1,565 282 -
REVIEW ARTICLE
Pharmacological evidences for the association of hypothyroidism with diabetes-mellitus
RK Goyal, R Kumar, JH McNeill
April-June 1990, 22(2):71-77
Full text not available  [PDF]
  1,302 179 -
SHORT COMMUNICATION
Pharmacological screening of some new 2 (substituted acetyl) Amino-5 Alkyl- 1, 3, 4 -Thiadiazoles
Mishra Pradeep, AK Shakva, RK Agrawal, GK Patnaik
April-June 1990, 22(2):113-116
1. Fifteen different 2 (substituted acetyl) amino-5-alkyl-I, 3, 4-thiadiazoles were synthesized. 2. These compounds were screened for spasmolytic and anti-inflammatory activities, 3. Compound AK-3, 2 (dimethyl amino acetyl) amino-5-propyl-1, 3, 4-thiadiazoles was found to possess potent spasmolytic activity. 4. Compound AK-5, 2 (diethyl amino acetyl) amino-5-ethyl 1, 3-4-thiadiazole was found to be an effective anti-inflammatory agent.
[ABSTRACT]   Full text not available  [PDF]
  1,188 246 -
Bronchorelaxant activity of Belamcanda chinensis (Adans)
Singh Surender, SS Agrawal
April-June 1990, 22(2):107-109
1. The extracts of Belamcanda chinensis (B. C.) were evaluated for branchorelaxant property against histamine aerosol induced bronchospasm. 2. The aqueous and 50% ethanolic extracts of its leaves and rhizomes exhibite significant protection against histamine induced pre-convulsive dyspnoea (PCD) in guinea pigs,
[ABSTRACT]   Full text not available  [PDF]
  1,203 135 -
Unusual adverse reactions to carbamazepine a report of 2 cases in India
Verma Kamini, KC Singhal, Kumar Sant
April-June 1990, 22(2):110-112
1. Two unusual cases of carbamazepine induced adverse reactions are reported. 2. A 15 years female developed Erythema multiforme-like drug eruptions with pustulation associated with involvement of gastrointestinal, hepatic and haematopoeitic systems, after carbamazepine therapy (200 mg x TDS). 3. Another female of 29 years developed urticarial rashes along with leucopenia with relative neutropenia, after only one day of therapy with carbamazepine (100 mg x TDS).
[ABSTRACT]   Full text not available  [PDF]
  1,133 167 -
RESEARCH PAPER
Exchange transfusion and biogenic amine status in acute fulminant hepatocellular failure in children
MS Krishnamoorthy, S Soundar, N Sundaravalli, S Karthikeyan
April-June 1990, 22(2):97-102
Full text not available  [PDF]
  1,162 75 -
SHORT COMMUNICATION
Ocular hypotensive effect of galanthamine hydrobromide - An experimental study
HC Agarwal, SK Gupta
April-June 1990, 22(2):117-118
1. The ocular hypotensive effect topical application (0.1, 0.25 and 0 5%) of galanthamine hydrobromide was studied on the normotensive rabbits eye. 2. Galanthamine hydrobromide produced significant fall (p
[ABSTRACT]   Full text not available  [PDF]
  1,154 76 -
RESEARCH PAPER
Effects of chronic Ethinyl estradiol treatment on the sensitivity of isolated rat vas deferens to various agonists
JD Bhatt, OD Gulati
April-June 1990, 22(2):78-84
1. In the present study ethinyl estradiol (EE) was administered chronically in dose of 1.5 mg/kg/day intramuscularly for 3 weeks and the sensitivity of isolated vas deferens of rat to various agonists was studied. 2. Chronic EE treatment significantly (P>0.05) decreased the EC50 values of norepinephrine (NE) and potassium chloride (KCl), while the EC50 values of acetylcholine, phenylephrine and methoxamine were unaltered. 3. Surgical denervation and acute in vitro pretreatment with cocaine (1 x 10-5M) of vas deferens, abolished the potentiating effects of chronic EE treatment on NE responses. 4. Phentolamine (1 x 10-6 ), a prototype alpha-blocker, also abolished the potentiating effects of EE treatment on KC1 responses. 5. It is concluded that chronic EE treatment of rat resulted in specific supersensitivity of vas deferens to NE, which is mediated through neuronal uptake blocking property.
[ABSTRACT]   Full text not available  [PDF]
  1,098 87 -
Effect of subacute exposure to DDT on pharmacokinetics of chloramphenicol in rabbits
Chugh Yati, A Sankaranarayanan, PL Sharma
April-June 1990, 22(2):92-96
Full text not available  [PDF]
  1,004 91 -
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