IPSIndian Journal of Pharmacology
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   1989| April-June  | Volume 21 | Issue 2  
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Pharmacology and biochemical evaluation of Tridax procumbens on inflammation
PV Diwan, Karwande Iravati, I Margaret, PB Sattur
April-June 1989, 21(2):1-7
1. Tridax procumbens (T. P.) was evaluated on various inflammatory models in rats and mice. 2. T. P. has significantly reduced exudate volume leucocyte migration, edema fluid, grannuloma tissue and (-glutamyl transpeptidase, indicates good anti-inflammatory action. 3. T. P. has negligible ulcerogenic property in comparison with NSAIAS. 4. T. P. causes anti-inflammatory activity through inhibiting SRs and PGs.
[ABSTRACT]   Full text not available  [PDF]
  7,155 888 -
Potential antifilarial activity of Streblus asper against Setaria cervi (nematoda: filarioidea)
Parveen Nazneen, KC Singhal, NU Khan, Singhal Parul
April-June 1989, 21(2):16-21
The effect of aqueous and alcoholic extract of Streblus asper was studied on the spontaneous movements of the whole worm and nerve-muscle preparation of Setaria cervi and on the survival of microfilariae in vitro. Aqueous as well as alcoholic extract caused inhibition of spontaneous motility of the whole worm and the nerve-muscle preparation of S cervi characterized by decreased tone, amplitude and rate of contractions. The concentration required to inhibit the movements of the nerve-muscle preparation was l/25 for aqueous and l/160 for alcoholic extract suggesting a cuticular permeability barrrier. The stimulatory response of acetylcholine was blocked by alcoholic and not by aqueous extract of S asper. Both alcoholic as well as aqueous extracts caused death of microfilariae in vitro, LC50 and LC90 being 90 and 33.5 ng/ml, respectively.
[ABSTRACT]   Full text not available  [PDF]
  2,231 150 -
A note on neuropsychopharmacological studies of Melia azedarach leaves
Verma Sandeep, ME Hamdard, PC Dandiya
April-June 1989, 21(2):46-50
1. Melia azedarach leaf extract potentiated pentobarbitone induced hypnosis in mice, lowered activity in the open field, decreased conditioned avoidance response and Techno wheel activity in rats, thus indicating a CNS depressant property. 2. It showed analgesic action as seen by the hot plate and also the acetic acid induced writhing method. 3 . It potentiated haloperidol induced catatonia, reduced the immobility of rats enhanced exploratory activity but like other CNS depressants (e.g. phenobarbitone) it reduced seizures. 4. It did not provide any protection against amphetamine toxicity in aggregated mice.
[ABSTRACT]   Full text not available  [PDF]
  1,549 230 -
Modified multiple choice reaction task test with improved sensitivity to detect psychopharmacological effect of drugs
BL Chauhan, KA Parvtrao, RD Kulkarni
April-June 1989, 21(2):8-15
1. Standardised multiple chosce reaction task test in respect of number of choice time interval, training and statistical analysis, so as to minimise inter and intraindividual variation in performance. 2. Application of this modified test to detect the effect of 5 mg of diazepam or 120 ml whisky in small number of healthy volunteers.
[ABSTRACT]   Full text not available  [PDF]
  1,505 96 -
Effects of scorpion venom (Buthus tamulus) on blood pressure, respiration and electrocardiographic recordings in anaesthetized albino rats
BG Patel, MI Bhatt, KC Dave
April-June 1989, 21(2):38-45
Full text not available  [PDF]
  1,402 131 -
Mechanism of acute pressor response to cadmium chloride
R Balaraman, OD Gulati, JD Bhatt, SP Rathod, KG Hemavathi
April-June 1989, 21(2):31-37
1. In rats, acute iv administration of CdCl2 (0.5 and 1 mg/kg) produced a depressor response followed by a pressor response while the acute i p administration of CdCI2 (0.5 and 1 mg/kg) produced only a pressor response. 2. Hexamethonium (10 mg/kg, i v), phentolamine (5 mg/kg, i v), propranolol (2 mg/kg, i v) or indomethacin (20 mg/kg, i p) did not modify the acute pressor response to CdCl2 (i v or i p). 3. Acute reserpinisation, bilateral adrenalectomy or chemical sympathectomy by guanethidine did not modify the acute pressor response to CdCI2 (i v or i p). 4. Verapamil(0.5, 1 and 2 mg/kg, i v) or nifedipine (0.25 and 0.5 mg/kg, i v) prevented the acute pressor response to CdCl2 (i v or i p). 5. It is concluded that cadmium might mimic calcium ion and produce a direct contractile effect on the vascular smooth muscle.
[ABSTRACT]   Full text not available  [PDF]
  1,366 85 -
Double blind cross-over clinical trial of metoprolol and propranolol in mild to moderate essential hypertension
Z Jeelani, SA Tanki, Y Kanjwal
April-June 1989, 21(2):51-53
Full text not available  [PDF]
  1,101 143 -
Influence of epinephrine and corticosterone on phosphatidate phosphohydralase activity in subcellular fractions of rat liver
Haghighi Bahram, Kargar Rasoul
April-June 1989, 21(2):22-30
Full text not available  [PDF]
  973 74 -
Depressor action of synthetic oxytocin and its dependence on sympathetic tone in rabbit
KU Ansari, VC Saksena
April-June 1989, 21(2):54-57
Full text not available  [PDF]
  944 81 -
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