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   1987| July-September  | Volume 19 | Issue 3  
 
 
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RESEARCH PAPER
Pharmacokinetic studies of metronidazole in goats
TK Mandal, KP Yadava, NC Banerjee
July-September 1987, 19(3):179-185
1. Pharmacokinefic studies of metronidazole in goats after single dose oral and i. v. administration at 50mg and 20 mg/kg respectively were carried out. 2. The mean blood level time profile obtained after oral administration showed maximum concentration C (max) at 2 b and the therapeutic concentration C (ther) in blood above 0.70 (g/ml persisted upto 6 h. 3. Metronidazole administered i. v. produced shorter duration of C (ther) with levels ranging from 2.29( 1.4 to 37.36( 1.5 Kg/ml till 2 h ; the drug attained C (maxI in milk at 1 b and Cm (ther) interestingly was maintained upto 12 h following i. v. administration. 4. The semilogrithmic plot of blood level time profiIe of metronidazoie administered i. v. showed biphasic decline which was suggestive of 'two compartment open model kinetics. 5. The elimination half life (t 0.5 ()and the apparent volume of distribution (V.d) were found to be 56(2.45 min and 0.93(0.96 L/kg respectively and the ratio of the microscopic rate constants (K12+K21)/K2 was also wider. 6. The extent of plasma protein bound drug ranged between 25.50 to 36.27 %
[ABSTRACT]   Full text not available  [PDF]
  3,585 121 -
Study of unani, polypharmaceutical preparation Joshina as antitussive and expectorant in experimental models
K Kheterpal, T Khanna, RB Arora, HH Siddiqui
July-September 1987, 19(3):200-204
1. Some of the pharmacological studies were performed on Joshina, a herbal polypharmaceutical, Unani Syrup given for cough, cold & catarrh. 2. The drug has significant antitussive activity against cough induced in guinea pigs by mechanical stimulation which is comparable with codeine (2Omg/kg, p. 0.). 3. Joshina is also found to have high potential as an antiinflammatory, decongestant and expectorant in experimental models. These activities are comparable with that of standard drugs such as phenylbutazone (85mg/kg., s. c.) and nor-adrenaling (l(g).
[ABSTRACT]   Full text not available  [PDF]
  2,167 237 -
Comparative bioavailability, pharmacokinetics and dosage regimen of three different brands of oxytetracycline in dairy cows after intramuscular administration
MK Singh, C Jayachandran, Prasad Surendra, BD Garg
July-September 1987, 19(3):192-199
1. Comparative bioavailability, pharmacokinetics and dosage regimen of three different commercial preparations of oxytetracyclime (Preparations X & Z-oxytetracycline hydrochloride; Preparation Y-oxytetracycline dihydrate) equivalent 0.5 mg/kg of base were studied post i. m. injection of the drugs in dairy cows. 2. Preparations Y and Z maintained a significantly low plasma concentration between 0.5 to 1 h and 2 to 8 respectively, as compared to preparation X. 3. No significant difference was observed for the drug concentration in milk among these preparations. 4. Kinetic parameters such as extrapolated zero time concentration during elimination phase (B), area under curve of plasma (AUC) were significantly lower while volume distribution (VdB ) and total body clearance (ClB ) were observed to he significantly higher for preparation Z as compared to preparation X. 5. There was no significant difference between the kinetic parameters of preparation X versus Y and Y versus Z. 6. The calculated dosage regimen of these preparations showed a significantly higher loading dose (D*) for preparation Z at the dosage interval of 12 h for maintaining C(pmin (MIC) of 0.5, 1.0 and 1.5(g/ml as compared to preparation X only.
[ABSTRACT]   Full text not available  [PDF]
  1,898 147 -
SHORT COMMUNICATION
Antibacterial activity of some active principles of Polyathia longifolia leaves
MM Goyal, Gupta Achla
July-September 1987, 19(3):216-220
1. Cuticuiar wax from the leaves of Polyalthia longifoiiu, Benth. & Hook. F. contains (a) hydrocarbons (C17-C35), (b) osters (C44-C58,) of long chain n-acids (C20-C30) and long chain O-aikanois (C24-C58), (c) biterpene alcohols consisting of , -amyrin, ( -amyrin and taraxasteroi and (d) pbytosterois consisting of , (-sitosterol, stigmasteroi, campesteroi and cholesterol. 2. The occurrence of tritriacontane (C33H58), in suhstantiai amounts (29.4%) is a unique feature of this plant. 3. The long chain hydrocarbons, triterpene alcohols and phytosterols exhibited concentration dependent inhibitory activity against eight types of bacteria.
[ABSTRACT]   Full text not available  [PDF]
  1,757 244 -
In vitro studies on protein binding of rifampicin
Polasa Kalpagam, K Krishnaswamy
July-September 1987, 19(3):225-229
1. Protein binding of rifampicin to varying albumin concentrations was carried out in vitro. Effect on other antitubercular drugs on protein binding of rifampicin was also studied. 2. The results indicated that rifampicin binding was influenced by albumin concentration, suggesting that it was chiefly bound to albumin. 3. Presence of other antitubercular drugs along with rifampicin decreased the percentage of bound rifampicin.
[ABSTRACT]   Full text not available  [PDF]
  1,553 202 -
LETTER
Effectiveness of cinkara a zinc rich herbal tonic on intellectual functioning of mentally subnormal children
NK Bohra, RB Arora, S Roy, EA Khan, Hameed HK Abdul
July-September 1987, 19(3):234-235
Full text not available  [PDF]
  1,517 164 -
RESEARCH PAPER
Secondary structure of neuropeptide Y
V Renugopalakrishnan, A Balasubramaniam, JC Dobbs, LA Carreira, RS Rapaka
July-September 1987, 19(3):174-178
1, The synthesis, biological activity and secondary structure of nenropeptide Y and its 4-Norleu analogue are discussed, The neuropeptides were synthesized by step-wise solid phase synthesis. 2. Secondary structures in aqueous solutions were investigated by CD and Raman spectroscopy. Chou-Fasman predictive algorithm were indicative of a N-terminal B turn segment followed by eithe u-helical or p-sheet sub-domain, which was consistent with experimental studies. 3. 4-Norleu-neuropeptide Y was more potent in inhibiting heart pace maker activity and coronary flow but less potent in inhibiting the cardiac contractility than native neuropeptide Y. The importance of the 4 positions in NPY in the cardiac activity is suggested. 4. A tentative secondary structural model for neuropeptide Y is proposed from the above studies.
[ABSTRACT]   Full text not available  [PDF]
  1,423 99 -
SHORT COMMUNICATION
Anti-inflammatory activity of total earthworm extract in rats
Yegnanarayan Radha, PP Sethi, PA Rajhans, K Pulandiran, SA Ismail
July-September 1987, 19(3):221-224
Full text not available  [PDF]
  1,313 192 -
REVIEW ARTICLE
Reorientation of medical education in Indian-an urgent need for reorganization of training in pharmacology
BP Jaju
July-September 1987, 19(3):205-215
Full text not available  [PDF]
  1,151 192 -
RESEARCH PAPER
Uptake and release of epinephrine in chicken liver: in vitro studies
AK Aggarwal, S Rishi, BD Garg
July-September 1987, 19(3):186-191
1. The epinephrine (E) content in white leg horn ( WLH ) chicken liver was estimated to be three-times less then norepinephrine (NE). 2. The liver slices were able to accumulate high concentration of E from the incubation media and this was found to be a concentration and time dependent phenomenon with peak accumulation occuring after 45 min. of incubation at 10-4M concentration of the amine. This process could be significantly blocked by cocaine, metanephrine and phenoxybenzamine. Following maximum accumulation, the amine showed linear disappearance when incubated in amine free media. 3. In tissue slices taken from reserpine treated group, the rate constant of disappearance (K) was much faster, decreasing its half life, as compared to control.
[ABSTRACT]   Full text not available  [PDF]
  1,098 86 -
LETTER
Enhancement of the antidotal action of atropine and trimedoxime by beta2-adrenergic agonists against fluostigmine in mice
RK Srivastava, AK Ghosh, Agarwal Mukesh, AS Sachar, Kumar Pravin, SK Sharma
July-September 1987, 19(3):230-233
Full text not available  [PDF]
  1,086 75 -
LETTER
An evaluation of the mutagenic potential of monocrotophos using micronucleus test
Kumar D Vijaya, A Janardhan
July-September 1987, 19(3):242-244
Full text not available  [PDF]
  875 127 -
Possible cholinergic modulation of clonidine and shock-induced aggression by thyroxine in albino mice
K Jain, FSK Barar
July-September 1987, 19(3):236-238
Full text not available  [PDF]
  866 71 -
LETTER
Effect of chloroquine on PGF2alpha responses of isolated guinea-pig ileum
A Kotwani, KC Dave, VL Mehta
July-September 1987, 19(3):239-241
Full text not available  [PDF]
  831 80 -
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