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   1987| April-June  | Volume 19 | Issue 2  
 
 
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SHORT COMMUNICATION
Imipramine and d-tubocurarine interaction in vivo
BG Patel, MI Bhatt, KC Dave
April-June 1987, 19(2):134-139
1. A non-paralysing dose of d-tubocurarine (25 (g/kg) caused quicker onset of hind limb paralysis of a long duration in rats pretreated with imipramine (15,30 mg/kg). Pretreatment with imipramine (10,15,30 mg/kg) in rabbits reduced the minimum effective head drop dose of d-tubocurarine. 2. Potentiating effect persisted upto 24 h, and total recovery from the effect appeared after 48 h, of imipramine (30 mg/kg) pretreatment, 3. It is suggested that the potentiation of the action of d-tubocurarine by imipramine may be of clinical importance, in patients receiving imipramine.
[ABSTRACT]   Full text not available  [PDF]
  2,250 80 -
Role of GABA in the anticonvulsant action of diazepam in albino mice
YV Rao, P Satishchandran, RP Kandlikar
April-June 1987, 19(2):140-144
1. Intraperitoneal diazepam (0.75-2.0 mg/kg) produced significant anticonvulsant effect in albino mice against pentylenetetrazol (80 mg/kg, SC) induced convulsions. 2. Pretreatment with thiosemicarbazide (5 mglkg, ip, 1 h), reduced the anticonvulsant effect of a sub-maximal dose of diazepam (1 mg/kg, ip, 2 h) whereas sodium valproate and muscimol (0,2 mg/kg, ip, 0.5 h) enhanced the effect of subanticonvulsant dose of diazepam (0.5 mg/kg, ip, 2 h) indicating the role of endogenous GABA in the effect of diazepam. 3. Biochemical studies also showed an increrse in cerebral cortical level of GABA in diazepam (1 mg/kg, ip, 2 h) or sodium valproate and diazepam (0.5 mg/kg, ip, 2 h) pretreated animals. Thiosemicarbazide pretreatment prevented the enhancement of cerebral cortical GABA level by diazepam (1 mg/kg, ip, 2 h).
[ABSTRACT]   Full text not available  [PDF]
  1,910 144 -
Pattern of prescribed and OTC drugs in north Goa
SS Hede, RS Diniz, NV Agshikar, VG Dhume
April-June 1987, 19(2):145-148
1. Analysis of drugs dispensed in four pharmacies of North Goa reveals that of the total 2456 drugs, 75.45 % were prescribed drugs whereas the remainder 24.55% comprised of OTC drugs. 2. Tonics, antibiotics and analgesics formed the highest percentage of prescribed drugs whereas tonics, analgesics and locally acting drugs formed the higbest percentage among OTC drugs. 3. Brand names were more prevalent than generic names. 4. Many drug combinations fulfilled the criteria of desirable drug interactions. No adverse drug interactions were obvious in any of the prescriptions together with the tendency of limited prescribing.
[ABSTRACT]   Full text not available  [PDF]
  1,643 184 -
RESEARCH PAPER
Cardiac effects of quercetin on the isolated rabbit and frog heart preparations
BB Bhansali, Vyas Subhash, RK Goyal
April-June 1987, 19(2):100-107
1. Quercetin produced dose dependent increase in force of contraction in isolated frog and rabbit heart preparations with simultaneous decrease in heart rate. 2. The dose dependent inotropic responses of quercetin were significantly inhibited by propranolol and practolol. Theophylline potentlated and imidazole attenuated the responses to quercetin significantly. 3. Quercetin responses were altered by changes in calcium chloride/sodium chloride/ potassium chloride concentrations In the perfusion fluid. 4. Ethylenediamine tetraacetic acid (EDTA), significantly inhibited the responses to querce tin. 5. The results suggest that quercetio induced positive inotropic effects are probably due to an increase in the availability of intracellular calcium.
[ABSTRACT]   Full text not available  [PDF]
  1,483 171 -
A study of nitrogen oxide containing vasodilators on guinea pig trachea, a nonvascular smooth muscle
P Bhugra, KG Hemavathi, OD Gulati
April-June 1985, 19(2):92-97
1. Sodium nitroprusside, sodium nitrite and papaverine produced concentration-dependent relaxation of guinea-pig isolated tracheal chain preparations contracted with KCI (20 mM), but had no effect on the resting tone of the preparation. 2. Methemoglobin and methylene blue known inhibitors of cGMP accumulation rightward shifts of concentration curves of sodium nitroprusside and sodium nitrite. 3. Neither methemoglobin nor methylene blue modified the papaverine-induced relaxation. 4. It is concluded that sodium nitroprusside and sodium nitrite induced relaxation of the guinea-pig trachea may be partly due to their cGMP elevating action. Papaverine induced relaxation seems to be totally independent of cGMP action.
[ABSTRACT]   Full text not available  [PDF]
  1,525 66 -
Altered digoxin levels in diabetic patients with congestive cardiac failure
RK Goyal, SM Jain, JJ Sheth, KC Dave, HC Mehta
April-June 1987, 19(2):117-123
1. The present investigation was undertaken to study the influence of diabetes mellitus on digozin levels in patients with congestive cardiac failure. 2. Serum digoxin levels were found to be significantly higher in diabetics (1.35 ( 0.2 ng/ml) as compared to nondiabetics (0.4 ( 0.04 ng/ml), with higher values in female patients as compared to males. 3. There was a correlation (r=0.5) between increase in digoxin levels andincrease in glycosylated haemoglobin value. 4. It is suggested that dosage regimes of the glycoside should be redesigned in diabetic patients to reduce the digoxin morbidity and mortality.
[ABSTRACT]   Full text not available  [PDF]
  1,411 135 -
Effect of chronic lead toxicity on the sensitivity of anococcygeus muscle of rat
RS Shah, AN Jain, Devan Aruna, RK Goyal
April-June 1987, 19(2):108-116
1. The present investigation was undertaken to study the effects of chronic lead toxicity on the sensitivity of rat anococcygeus muscle to various agonists. 2. Treatment of rats with lead acetate (6.5 mg/kg/day, i,p. for 21 days) resulted in significant elevation of blood level and ( -aminolevulnic acid in urine ( ( -ALA-U). 3. The anococcygeus muscle isolated from lead treated rats exhibited supersensitivity to noradrenaline, dopamine, carbachol and 5-hydroxytryptamine. 4. Deprivation of Cat-t from the bathing medium did not alter significantly the responses to these agonists, however the supersensitivity was completely abolished in anococcy-geus muscle preparations obtained from lead treated animals. 5. The supersensitivity to these agonists was maintained in lead treated preparations bathed in medium containing high Ca++. 6. Ca Cl2 produced a dose depeodent contraction in the presence of sub-threshold dose of various agonists. These responses were significantly increased in lead treated preparations. 7. Our data indicate that chronic lead toxicity produces supersensitivity to various agonists in rat anococcygeus muscle.The mechanism of this supersensitivity may be related to an increased availability of calcium and/or increased sensitivity to the calcium of the tissues.
[ABSTRACT]   Full text not available  [PDF]
  1,429 111 -
LETTER
Thiophanate methyl acute, subacute and chronic toxicity in rats
TJ Singh, BD Garg, PC Verma
April-June 1987, 19(2):159-161
Full text not available  [PDF]
  1,338 184 -
RESEARCH PAPER
Comparative biochemical and haematological study of enfenamic acid and some non-steroidal anti-inflammatory drugs
SVV Sharma, VK Kulshrestha
April-June 1987, 19(2):94-99
1. Comparative evaluation of enfenamic acid and few NSAID was done on biochemical parameters like blood sugar and uric acid and on baematological parameters like clotting time, platelet count, euglobulin clot lysis time and plsma fibrinogen content in rabbits. 2. Aspirin and ibuprofen per se induced hyperglycemia while tolmetin and indometbacin produced hypoglycaemic response.However, with enfenamic acid, hypoglycaemlc resposne was more marked in higher doses. Aspirin and tolmetin exhibited significant hypouricaemic effect, enfenamic acid and ibuprofen were less potent in this respect. 3. Thrombocytopenia and decrease in coagulation time was observed with aspirin, indometbacin, tolmetin and ibuprofen However, enfenamic acid failed to affect these para-meters. 4. Our study showed increased plasma fibrinogen content and euglobulin clot lysis time with aspirin, tolmetin and indomethacin while ibuprofen produced an increase in plasma fibrinogen content and had no effect on euglobulin clot lysis time; enfenamic acid had no effect on both the parameters.
[ABSTRACT]   Full text not available  [PDF]
  1,355 108 -
Comparative evaluation of antiulcer effects of antidepressants
VS Jaguste, VN Dadkar, SA Kerkar, FR Billimoria, HL Dhar
April-June 1987, 19(2):85-93
1. In an investigation of antiulcer potential of various antidepressants it was observed that trimipramine, nomifensine and mianserin (10 mg/kg i.p. 60 min prior) offered protection, against restraint stress (18 hour), aspirin (225 mg/kg, p.o. 4 hrs prior) and piroxicam (10 mg/kg i.p. 2 hrs prior) induced gastric ulcers. Iprindole, however, failed to offer significant protection. 2. Decrease in gastric mucosal sialic acid and hydroxyproline content, decrease in thymic and spienic weight and depletion of adrenal ascorbic acid on account of restraint stress were found to improve only with pretreatment with trimipramine, but not with iprindole. 3. Antiulcer effect of trimipramine, nomifensine and mianserin is likely to be on account of their property of increasing central norephtephrine which in turn improves gastric function.
[ABSTRACT]   Full text not available  [PDF]
  1,260 175 -
REVIEW ARTICLE
Specific instructional objectives for experimental pharmacology practicals for medical college students
NA Kshirsagar, NN Rege, SM Karandikar
April-June 1987, 19(2):124-129
Full text not available  [PDF]
  1,268 156 -
Theophylline: a reappraisal
Subramaniam Swaminathan, Dhand Rajiv, SK Garg, PL Sharma
April-June 1987, 19(2):74-84
Full text not available  [PDF]
  1,266 129 -
LETTER
Effect of electroconvulsive therapy on alloxan induced diabetes in rats
G Sivagnanam, B Gitanjali, R Raveendran, C Adithan, JS Bapna
April-June 1987, 19(2):153-155
Full text not available  [PDF]
  1,151 207 -
SHORT COMMUNICATION
Effect of scoparone on tissue catecholamine content
ML Sharma
April-June 1987, 19(2):130-133
1. The effect of scoparone on catecholamine content of adrenal glands, spleen, brain and intestinal tissues of rats was investigated. 2. A single oral dose of scoparone (100 mg/kg-1) produced reduction of catecholamine content of adrenal glands and spleen without affecting that of brain, heart and small intestines. 3. On repeated oral administration also, it lowered the catecholamine content of the adrenal glands but not that of brain. 4. The catecholamine lowering effect appeared within 6h, and was maximum at 24 h. The hypotensive and tranquillosedative effects of scoparone appeared within 15-20 min after oral administration and lasted for 4-6 h.The pharmacological effects of scoparone, therefore, appear to be independent of its catecholamine depleting action.
[ABSTRACT]   Full text not available  [PDF]
  1,251 74 -
LETTER
Hypotensive agents decrease locomotor activity in mice
PP Singh, AY Junnarkar, RK Verma
April-June 1987, 19(2):170-173
Full text not available  [PDF]
  1,087 108 -
Interaction of metoprolol with some sympathomimetic amines on dog blood pressure
PS Zaae, MK Jagtap
April-June 1987, 19(2):162-165
Full text not available  [PDF]
  1,113 77 -
Biotransformation of intravenously administered tris (2-ethyl hexyl) trimellitate (Hatcol-200) in rabbits
K Rathinam
April-June 1987, 19(2):149-152
Full text not available  [PDF]
  1,063 104 -
Effects of alpha-1 and alpha-2 adrenergic antagonists on hyperglycemia induced by adrenaline in rabbits
SA Bhounsule, VG Dhume, VR Naik, NV Agshikar
April-June 1987, 19(2):166-169
Full text not available  [PDF]
  1,060 83 -
Decreased antipyrine and paracetamol clearance in leprosy
D Chandra, K Ray, R Bansal, CM Rao
April-June 1987, 19(2):156-158
Full text not available  [PDF]
  976 83 -
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