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   1987| January-March  | Volume 19 | Issue 1  
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Effect of butanolic extract of Pueraria tuberosa DC. on the oestrous cycle of adult rats
Shukla Sangeeta, R Mathur, AO Prakash
January-March 1987, 19(1):49-53
1. The effect of butanolic extract of Pueraria tuberosa DC has been studied on the duration of oestrous cycle in adult cyclic rats. 2. The extract at 150 mg/kg dose induced cornified phase at the initial days of treatment which persisted till the last day of treatment. 3. Induction and persistance of cornification in the oestrous cycle due to the treatment of butanolic extract has been accounted for its estrogenic nature.
[ABSTRACT]   Full text not available  [PDF]
  4,068 297 -
Aristolic acid an antifertility agent is non-mutagenic to bacterial system
SN Chakrabarty, A Pakrashi, KAI Siddiqui
January-March 1987, 19(1):26-31
1. Aristolic acid, a potential antifertility agent was found not mutagenic in Ames test. On the other hand aristolochic acid and analogue of aristolit acid was mutagenic. 2. The presence of nitrovinyl group in the phenantnrene molecule seemed to be essential for mutagenic property.
[ABSTRACT]   Full text not available  [PDF]
  1,657 130 -
Effect of chronic treatment of estrogen and progesterone on histamine receptor sensitivity in guinea-pig uterus
DD Desai, AN Jain, RK Goyal
January-March 1987, 19(1):19-25
1. In the present investigation the influence of estrogen and progesterone on the histamine induced responses in guinea pig uterus was studied. 2. The responses to histamine were significantly decreased in preparations pretreated with estrogen (pD2=4.75) or progesterone (pD2=5.27). 3. Blockade of responses to histamine by mepyramine after estrogen (pA2=8.65) and progesterone pretreatment (pA2=9.1 1) were significantly less than the control. 4. Dose dependant contractile responses of guinea-pig uterus were obtained with 2 - (2 pyridyl) ethylamine (pO2=5.95) which decreased after estrogen pretreatment (pD2=4 .35) or progesterone pretreatment (pD2=4.87). 5. The data suggest a decrease in H1 receptor sensitivity in guinea pig uterus after estrogen or progesterone pretreatment.
[ABSTRACT]   Full text not available  [PDF]
  1,648 88 -
Local anaesthetic activity of 9-alkylamino-1,2,3,4,-tetrahydroacridines: structure-activity relationship study
SN Rastogi, GK Patnaik, BN Dhawan
January-March 1987, 19(1):44-48
1. A series of 9-alkylamino-1, 2, 3, 4-tetrahydroacridines and analogues were synthesized and tested for local ansesthetic activity in rabbits and guinea pigs. 2. 9-n-Heptylamino-1, 2, 3, 4-tetrahydroacridines showed the maximum activity and were more potent than lignocaine. 3. The local anaesthetic activity seems to be partly influenced by the lipophilicity of the compounds.
[ABSTRACT]   Full text not available  [PDF]
  1,385 117 -
Effect of thiophanate methyl on central nervous system
TJ Singh, BD Garg
January-March 1987, 19(1):32-36
1. Thiophanate methyl decreased spontaneous motor activity and body temperature. 2. It had no effect on pentobarbitone sleeping time, forced coordinated motor activity, conditioned avoidence response,convulsions induced by electrical stimulation or by pentylenetetrazol and did not exhibit local anaesthetic activity, 3. It had a significant analgesic effect.
[ABSTRACT]   Full text not available  [PDF]
  1,306 102 -
Relaxant effect of dopamine and its analogues on the isolated guinea-pig tracheal chain; with some observations on structure-activity relationships
Lal Ramesh, PL Sharma
January-March 1987, 19(1):54-58
1. The per se reIaxant effect of dopamine and its different analogues, with different substituents on nitrogen atom and alpha carbon atom, was studied on the isolated guinea pig tracheal chain. Isoprenaline and ritodrine were used as standards for comparison. 2. All the dopamine analogues, like isoprenaline and ritodrine, produced dose-dependent relaxation.The relaxant effect produced by alpha-methyl-isopropyl- dopamine and dobutamine was quite comparable to ritodrine but was less than that of isoprenaline.The activity of phenyl-secondary-butyl-dopamine was some what less than that of ritodrine.
[ABSTRACT]   Full text not available  [PDF]
  1,303 90 -
Antinociceptive, anticonvulsant and anti-inflammatory activities of Zizyphus xylopyra
YB Rao, Dewi, JP Singh, VB Panday
January-March 1987, 19(1):63-65
Full text not available  [PDF]
  1,165 169 -
Propranolol in first order relatives of hypertensive subjects
Yegnanarayan Radha, DS Shroti
January-March 1987, 19(1):37-43
1. Autonomic over activity is known to precede overt hypertension, and with intervention at this stage it could be possible to delay and minimise further elevation in blood pressure. 2. In the present study propranolol 20 mg/day has been tried in first order relatives of hypertensives who showed hyperresponsiveness in manoevures like cold pressor test and Valsalva manoevure which involve reflex sympathetic activity. Propranolol was effective in reducing the exaggerated response without causing overt cardiovascular effects.
[ABSTRACT]   Full text not available  [PDF]
  1,213 87 -
Influence of diet on serum and urinary levels of rifampicin
SD Prohit, ML Gupta, SL Gehlot, PR Gupta, YR Mehta, D Jain, SK Sarkar
January-March 1987, 19(1):59-62
Full text not available  [PDF]
  1,185 92 -
On the chromatographic profile of sodium chloride injection
K Sreenivasan
January-March 1987, 19(1):70-73
Full text not available  [PDF]
  1,150 84 -
Concept of pharmacological and evolution of pharmacological thought
Singh Manjeet
January-March 1987, 19(1):9-18
Full text not available  [PDF]
  1,035 176 -
Role of prostaglandins in neuroleptic and narcotic catalepsy
AS Kapoor, SK Bhattacharya, PN Singh
January-March 1987, 19(1):1-8
Full text not available  [PDF]
  1,000 119 -
Effects of MK-212 (6-chloro 2-(-1 piperazinyl) pyrazine and 5-hydroxy tryptamine on various smooth muscle preparations.
M Dinesh, Patel, KR Goyal
January-March 1987, 19(1):66-69
Full text not available  [PDF]
  980 72 -
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