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   1986| July-September  | Volume 18 | Issue 3  
 
 
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RESEARCH PAPER
Vitamin A reverses the wound-healing suppressant effect of cyclophosphamide
SS Raju, DR Kulkarni
July-September 1986, 18(3):154-157
1. Vitamin A has been reported to be an antineoplastic and also claimed to promote wound healing. 2. Vitamin A effects on cyclophosphamide induced suppression of healing was investigated in two wound models, viz: resutured incision and full thickness excision wound in rats. 3. Cyclophosphamide (60 mg/kg ipon3rd wounding day)significantly reduced tensile strength (incision wounds), extended epithelization period, suppressed wound contraction and increased scar size (excision wound) 4. Vitamin A (5000 IU, sc altrenate day) reversed the above deffects of cyclophosphamide. 5. In excision wounds the vitamin promoted epithelization and contraction even in the absence of cyclophosphamide suppression. 6. It is concluded that vitamin A reverses wound-healing suppressant effect of cyclophosphamide and also promotes normally progressing healing of excision wounds.
[ABSTRACT]   Full text not available  [PDF]
  3,211 255 -
RESEARCH PAPER
Antimicrobial and infected wound healing response of some traditional drugs
AM Thaker, JV Anjaria
July-September 1986, 18(3):171-174
1. Significant inhibition of growth of staphylococcus aures, streptococcus pyogenes, corynebacterium spp., escherichia coli, and pseudomonas aeruginosa was observed in vitro by traditional drugs like Ocimum Sanctum, Azadirachta indica, Annona squamosa and Bergia odorata. 2. Healing of the wound by indigenous ointment formulation was comparable to that of nitrofurazone and little better than propamidine cream in mice infected by the oraganisms. The indigenous plant material understudy showed significant inhibition of pathogenic microorganisms and effective healing of infected wounds.
[ABSTRACT]   Full text not available  [PDF]
  2,463 654 -
LETTER
Mechanism of cholesterol lowering effect of Salai guggal ex.boswellia serrata roxb
U Zutshi, PG Rao, S Kaur, GB Singh, Singh Surjeet, CK Atal
July-September 1986, 18(3):182-183
Full text not available  [PDF]
  2,107 229 -
RESEARCH PAPER
Correlation of serum total and free phenytoin levels with drug intake and seizure control
SN Ahmad, NF Jaffery, GK Ahuja, BL Jailkhani
July-September 1986, 18(3):144-148
1. Sera of 92 epileptic patients, receiving phenytoin (3-7mg/kg/per day) alone/ in combination with phenobarbitone (1-2 mg/kg/day), were analysed for total and free phenytoin spectrophotometrically. 2. The respective means of total and free phenytoin in the phenytoin group were not significantly different from the phenytoin plus phenobarbitone group. 3. The relationshp between total and free phenytoin, in all patients, was curvilinear i.e. biphasic. The proportion of free phenytoin in patients with total phenytoin <20(g/ml was significantly (p<0.01) higher than those with total phenytoin <20 (g/ml 4. Compared to uncontrolled patients the controlled patients without toxicity showed no statistical differences in mean levels of total and free phenytoin; significantly higher proportion of free drug and a tendency to maintain higher levels of both free and total drug at a given dose, and a significant rise in these levels with dosage increment. 5. The mean total and free phenytoin levels in patients who developed toxicity were higher than the uncontrolled as well as controlled patients without toxicity.
[ABSTRACT]   Full text not available  [PDF]
  1,903 140 -
RESEARCH PAPER
Effect of -adrenoceptor antagonists on tolbutamide induced hypoglycaemia and its half life in rabbits
H Kumar, VV Sharma, VK Kulshrestha
July-September 1986, 18(3):139-143
1. Interaction of tolbutamide with some betaadrenoceptor antagonist was studied in normal and alloxan-induced diabetic rabbits. 2. Propranolol and atenolol per se produced hypoglycaemia and potentiated tolbutamide effect also. However, on concurrent administration they failed to influence serum concentration pattern and half life of tolbutamide in normal as well as diabetic rabbits. 3. Metoproiol and acebutolol, both cardio-selective ( blockers, per se neither produced any change in blood sugar level nor influenced tolbutamide hypoglycaemia and its serum level. 4. In diabetic rabbits, all the (adrenergic blockers studied, potentiated tolbutamide hypoglycaemia. 5. In the animals pretreated with (adrenergic blockers for 7days,only propranolol and atenoiol potentiated tolbutamide hypoglycaemia but the serum tolbutamide level remained unchanged.
[ABSTRACT]   Full text not available  [PDF]
  1,429 99 -
RESEARCH PAPER
Autonomic nervous transmission in crop of domestic fowl
SK Garg, BD Garg, SP Verma, RD Rana
July-September 1986, 18(3):163-167
1. Adenine nucleotides produced contraction dependent contraction of crop. The order of potency was: ATP> ADP> AMP. The response of ATP was blocked by promethazine, cyproheptadine, caffeine and partially reduced by atropine. Electrical stimulation of the innervating nerves caused a contraction followed by relaxation up to 80 percent. 2. Electrical Stiulation of the innervating nerves caused a constraction followed by relaxation up to 80 percent. 3. The initial contraction was blocked by atropine and the residual contraction was blocked by cyproheptadine. The response was almost completely blocked by promethazine (104 M) but was not altered at all by caffeine (10 M) tolazoline (104 M) or propranolol (104 M) 4. lt is likely that ATP is acting on the release or receptors of histamine or 5-HT.
[ABSTRACT]   Full text not available  [PDF]
  1,397 93 -
SHORT COMMUNICATION
The bronchorelaxant effect of oxytocin in guinea pigs
Chandra Dinesh
July-September 1986, 18(3):175-177
1. Bronchorelaxant effect of graded doses oxytocin in guinea pigs was studied employing in vitro and in vivo experiments 2. In vitro studies the 50% relaxant dose (EC 50) of oxytocin against histamine, carbachol and barium chloride were in close approximation. Lndomethacin pretreatment and compound SC 19220 increased the EC 50 of oxytocin. 3. In vivo experiments ip oxytocin prolonged the preconvulsive time.
[ABSTRACT]   Full text not available  [PDF]
  1,198 89 -
RESEARCH PAPER
Hemolytic effect of acetylsalicylic acid in G-6-PD deficient and normal erythrocytes
R Nagarajan, N Murugesh, S Vembar
July-September 1986, 18(3):149-153
1. In the present study it has been shown that acetylsalicylic acid (ASA) produces hemolysis of both normal and G-6-PD deficient erythrocytes. 2. The degree of hemolysis is almost the same in both the erythrocytes. 3. Acetylation and peroxidation of membrane lipid do not appear to be necessary for the hemolytic effect of ASA. 4. Severe membrane damage as evident from the liberation of phospholipids and sterols appears to be the mechanism by which ASA produces hemolysis.
[ABSTRACT]   Full text not available  [PDF]
  1,180 91 -
Effects of levamisole on isolated anococcygeus muscle of rat
KK Shah, OD Gulati, KG Hemavathi
July-September 1986, 18(3):158-162
1. Effects of levamisole (Lev) were investigated on the rat isolated anococcygeus muscle. 2. Lev in low concentration (2.8x10-5 M) per se elicited no contractile effect on the Prepration but potentiated (P<0.05) the responses to noradrenaline (3.13x10-8 M to 9.39x10-7 M). 3. Higher concentrations of lev (4.15x10-5 M to 1.24x10-3 M) elicited dose-related contractile responses, which were blocked by phentolamine (3.26xlO-8M). 4. In reserpinized tissue the dose-response curve of lev was inhibited ( p<0.01) 5. Pretreatment with cocaine (8.83x10-6M and 2.94x10-5 M), normetanephrine (5.46 x lO-5 M), nialamide (3.35 X $a1 10-5M) or tropolone (4.1 X 1O-4M) and combination of nialamide and tropolone significantly (p
[ABSTRACT]   Full text not available  [PDF]
  1,061 100 -
Cardiovascular effects of 2-stimulants and their mechanisms
MP Shrivastava, SD Dharmadhikari, KJ Gharpure, PG Dasputra
July-September 1986, 18(3):168-170
1. The study was conducted in 5 healthy human volunteers to compare the effect on heart rate and blood pressure of three (2 , stimulants, salbutamol (4 mg) terbutaline (5 mg) and orciprenaline (20 mg). Two beta blockers, propranolol (40 mg) and metoprolol (50 mg) were also used to elucidate underlying mechanisms 2. All three (2 stimulants produced increase in heart rate (HR) and systolic BP and a fall in diastolic BP. 3. Effect on HR seems to be through cardiac (land. (2 receptors. 4. Effect on syst. B P seems to be through (I receptors. 5. Fall in diastolic B P seems to be mediated through (2 receptors.
[ABSTRACT]   Full text not available  [PDF]
  1,044 93 -
REVIEW ARTICLE
Benzodiazepines: their pharmacological basis and present status in therapy
PC Dandiya, P Banerjee
July-September 1986, 18(3):131-138
Full text not available  [PDF]
  880 249 -
LETTER
Effect of -alanine on skin homografts in rats: an experimental study
MS Bal, BR Madan
July-September 1986, 18(3):180-181
Full text not available  [PDF]
  1,016 75 -
Epileptogenic properties of various penicillins in mice
RC Rane, TP Gandhi, RB Patel, GF Shah, JD Raval
July-September 1986, 18(3):178-179
Full text not available  [PDF]
  936 69 -
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