IPSIndian Journal of Pharmacology
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   1985| April-June  | Volume 17 | Issue 2  
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Neuroleptic therapy and antihistaminic drugs: a pharmacological study
TJ Hemnani, SB Patel, PG Dashputra
April-June 1985, 17(2):98-102
(1) The antipsychotic effects of chlorpromazine have been potentiated by mepyramine and pheniramine, unaffected by diphenhydramine and meclizine, while it is antagonised by promethazine. (2) Regarding extrapyramidal effects, promethazine, diphenhydramine and mepyramine have strong antagonising effect as compared to pheniramine and meclizine. (3) Comparison of risk-benefit ratio, suggest that during neuroleptic therapy, the prophylactic use of promethazine has harmful effect, diphenhydramine and meclizine have no effect, while mepyramine and pheniramine have a beneficial effect.
[ABSTRACT]   Full text not available  [PDF]
  1,798 157 -
Anti-inflammatory activity of substituted guanidine hydrochlorides
Saxena Archna, Aron Rina, SC Mehra, SK Tandan
April-June 1985, 17(2):113-115
1. Twelve different substituted guanidines were prepared by the condensation of different heterocyclic moieties with different aryl cyanamides. 2. Compounds were screened for anti-inflammatory activity and compared with standard drug phenylbutazone. 3. Ten compounds showed significant anti-inflammatory activity and compound IV, N-P-anisyl-N'-5-phenyl-1,3,4-oxadiazol-2-yl guanidine hydrochloride, was the most potent In carrageenin-induced oedema.
[ABSTRACT]   Full text not available  [PDF]
  1,230 241 -
Effect of antiarrhythmic drugs on ventricular fibrillation threshold and cardiac stores of norepinephrine in the cat.
M Pande, K Kar, BN Dhawan
April-June 1985, 17(2):103-107
1. Comparative evaluation of the effect of anti-arrhythmic drugs on ventricular fibrillation threshold (VFT) and on theconcentration of norepinephrine (NE) in the different parts of the myocardium of the cat has been undertaken. 2. In pentobarbitone anaesthetised cats fibrillation induced by electrical stimulation (ES.) of the left ventricle caused reduction of NE in the heart. 3. Quinidine and disopyramide, the membrane stabilizers; lidocaine, a local anaesthetic; adrenergic receptor blockers like phenoxybenzamineand propranoloI, and verapamil, a calcium antagonist, caused bradycardia, hypotension and decrease in NE content. 4. Pretreatment with quinidine, disopyramideand lidocaine inhibited further release of NE from the myocardium following E.S. and significantly raised VFT. 5. Phenoxybenzamine (10 mg/kg), propranolol (5 mg/kg) and verapamil (1 mg/kg) did not inhibit the release of NE. Phenoxybenzamine provided protection against ventricular fibrillation whereas propranolol and verapamil failed. 6. The results suggest the involvement of ( adrenergic receptor as a contributing factor in the onset of ventricular fibrillation induced by E.S.
[ABSTRACT]   Full text not available  [PDF]
  1,377 86 -
Basic programs for pharmacokinetic analysis on microcomputer
PM Nadkarni, PM Nadkarni, NA Kshirsagar
April-June 1985, 17(2):88-91
1. Computer programs for pharmacokinetic analysis have been written in the language BASIC for use on microcomputer. 2. Three programs incorporating respectively the Back-Projection, Wagner-Nelson, and Loo-Riegelman algorithms can estimate the constants for the absorption, distribution and elimination phases of the concentration-time curve, as well as area-under curve. 3. The programs are valid for first-order kinetics. Use of the programs does not require knowledge of programming.
[ABSTRACT]   Full text not available  [PDF]
  1,184 110 -
Behavioural evidence for direct stimulation of rat brain 5-Hydroxytryptamine receptors by ergometrine
TR Bapat, VP Gada, NV Nandal, JJ Balsara, AG Chandorkar
April-June 1985, 17(2):108-112
1. Ergometrine produced a behavioural syndrome in the rat which was characterized by head and body shakes, lateral head weaving, forepaw treading, hindlimb abduction and Straub tail. 2. Pretreatment with 5-HT receptor antagonists, cyproheptadine and methysergide, significantly decreased the intensity of the behavioural syndrome produced by ergometrine. 3. Pretreatment with p-chlorophenylalanine and clomipramine significantly decreased the intensity of the behavioural syndromes induced by fenfluramine and p-chloramphetamine but had no significant effect on the intensity of the behavioural syndrome produced by ergometrine. 4. The results indicate that ergometrine produces the 5-HT mediated behavioural syndrome by directly stimulating the central 5-HT receptors.
[ABSTRACT]   Full text not available  [PDF]
  1,182 69 -
Bioinequivalence: an overview of the national versus international digoxin scene
M Bansinath, VS Mathur
April-June 1985, 17(2):81-87
Full text not available  [PDF]
  1,100 143 -
High performance liquid chromatographic method for serum antipyrine estimation
JP Jani, JS Patel, MP Shah, MR Variya, YH Shah, SK Kashysap
April-June 1985, 17(2):116-117
Full text not available  [PDF]
  897 109 -
Pharmacology in India
RK Raina
April-June 1985, 17(2):79-80
Full text not available  [PDF]
  905 77 -
Inhibitory effect of enfenamic acid on protein biosynthesis in mouse liver cell free system in vitro
TLV Sreenath, H Polasa
April-June 1985, 17(2):118-119
Full text not available  [PDF]
  857 57 -
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