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   1984| July-September  | Volume 16 | Issue 3  
 
 
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RESEARCH PAPER
An experimental study of analgesic activity of Cissus quadrangularis
SP Singh, N Misra, KS Dixit, N Singh, RP Kohli
July-September 1984, 16(3):162-163
1. The analgesic activity of alcoholic extract of whole plant of cissus quadrangularis family vitaceae), was studied in mice by Haffner's Clip and Eddy's hot plate methods. 2. The extract effective by both oral and i.p. routes significantly (P < 0.001) increased the reaction time by both methods. 3. The duration of analgesic activity was from 2 to 4 h and optimum effect was observed at l/20th -1/10th of LD50 dose. The extract compared well with acetylsalicylic acid.
[ABSTRACT]   Full text not available  [PDF] [CITATIONS]
  4,024 644 6
Anti-inflammatory and other pharmacological effects of Hedychium spicatum (Buch-Hem)
RC Srimal, SC Sharma, JS Tandon
July-September 1984, 16(3):143-147
1. Investigation of the biological activity of rhizomes indicate that they possess anti-inflammatory and analgesic activity. 2. The anti-inflammatory activity was localised mainly in the hexane fraction from which one of the pure active constituents, hedychenone has been isolated. The analgesic activity was more prominent in the benzene fraction. 3. Some other minor active constituents are also present which may contribute to the total activity of the rhizomes.
[ABSTRACT]   Full text not available  [PDF] [CITATIONS]
  3,385 666 17
Protective effect of Tinospora cardiofola miers on carbon Tetrachloride induced hepatotoxicity
B Singh, ML Sharma, DK Gupta, CK Atal, RK Arya
July-September 1984, 16(3):139-142
1. Tinospora cardifolia Miers is reputed to possess beneficial effects in liver ailments in Ayurvedic medicine. 2. Aqueous suspension of alcoholic extract was subjected to pharmacological investigations for hepatoprotective activity. 3. The extract did not effect the hexobarbitone and pentobarbitone induced sleeping time in normal rats and mice 4. In carbon tetrachloriie induced hepatic injury in rats it maintained the hexobarbitone induced sleeping time, serum glutamic oxaxacetic transaminase, glutamic pyruvic transaminase and alkaline phosphatase levels equivalent to the control values and protected the hepatic architecture. 5. It also significantly reduced bromsulphthalein clearance time in carbon tetrachloride treated rabbits and increased bile flow in rats.
[ABSTRACT]   Full text not available  [PDF] [CITATIONS]
  1,580 240 7
The central effects of Lycopersicon esculentum (Tomato) leaves
KMY Amin, KC Singhal, Chandra Om
July-September 1984, 16(3):148-152
1. The central effect of aqueous and alcoholic extracts of the leaves of Lycopersicon esculentum (tomato) were studied. 2. The extracts exhibited central depressant activity and analgesic activity and blocked conditioned avoidance response. 3. It appears that the active principles responsible for central effects are other than tomatine. 4. The alcoholic extract produced a higher modality of central depression than the aqueous .extract.
[ABSTRACT]   Full text not available  [PDF]
  1,323 171 -
Effect of alloxan on some parameters of lenticular pathway in rat glutathione and glutathione reductase
UM Rawal, DN Gandhi
July-September 1984, 16(3):158-161
1. The effect of alloxan, a sugar cataractogenic substance on glutathione (GSH) and glutathione reductase (GSH-R) activity in blood, aqueous humor and lenses of normal and treated rats is reported. 2.In contrast to normal lenses, alloxan induced cataractous lenses showed an i ncrease in CSH-R activity and fall in CSH content in blood, aqueous humor and Iens indicating that alloxan may interfere with intracellular oxidation reduction process in the lens and thus lead to cataract formation.
[ABSTRACT]   Full text not available  [PDF]
  1,316 111 -
LETTER
Amino acids as anti-inflammatory agents
NK Khanna
July-September 1984, 16(3):122-123
Full text not available  [PDF]
  1,276 140 -
RESEARCH PAPER
Effect of propranolol on aggressive behaviour in rats
A Ray, M Alkondon, P Sen
July-September 1984, 16(3):129-131
1. (Propranolol in doses of 1 and 3 mg/kg facilitated whereas 10 and 30 mg/kg inhibited footshock aggression (FSA) in rats. 2. Atropine but not atropine methylnitrate antagonised the antiaggressive effect of (() propranolol (IO mg/kg) wlthout affecting the facilitatory affect on FSA. 3. Racemic propranolol (1 and 10 mg/kg) also antagonised reserpine apomorphine aggression. 4. It is suggested that central cholinergic as well as dopaminergic mechanisms could be involved in the anti-aggressive effect of propranolol.
[ABSTRACT]   Full text not available  [PDF]
  1,263 79 -
RESEARCH PAPER
Effect of cimetidine and sodium cromoglycate combinations on gastric acidity and gastric ulcers in rabbits and rats
MM Singh, DK Basu
July-September 1984, 16(3):136-138
1. Cimetidine (37.5 (g/kg) and disodium cromoglycate (20(g/kg) in combination produced 80.33% and 81.68% inhibition of free and total acidity respectively in rabbits from control value (P < 0.01). 2. Aspirin induced ulcers in rats were inhibited by prior administration of cimetidine or disodium cromoglycate. However, when the latter drugs were used in combination, the ulcer protection effect was significantly enhanced.
[ABSTRACT]   Full text not available  [PDF]
  1,211 112 -
RESEARCH PAPER
Effect of concurrent use of cimetidine and anti-inflammatory agents in experimental models of peptic ulcer and inflammation
AK Mahajan, Singh Hardyal, BS Tung
July-September 1984, 16(3):132-135
1. Cimetidine (20 mg/kg/i.p) inhibited the peptic ulcer-index in histamine treated adult albino rats and afforded a protection of 22% and 23% respectively in hydrocortisone (7.5 mg/kg/i.p) and phenylbutazone (1.5 mg/kg/i.p) pretreated and similarly challenged animals. 2. Hydrocortisone and phenylbutazone in the aforementioned doses significantly inhibited the dextran/carrageenin induced oedema and cotton pellet granuloma. 3. Concurrent use of cimetidine did not significantly affect the antiinflammatory potential of phenylbutazone or hydrocortisone nor did it on its own modify any of the tested phase of inflammation.
[ABSTRACT]   Full text not available  [PDF]
  1,144 145 -
Biochemical and hematological effects of tolmetin, a new nonsteriodal anti-inflammatory drug
N Sangal, BB Nayak, VV Sharma, MB Mishra, VK Kulshrestha
July-September 1984, 16(3):153-157
1. The biochemical and haematological effects of tolmetin (a pyrole acetic acid derivative), on blood sugar,' serum cholesterol, serum uric acid, blood count, coagulation time, plasma fibrinogen content and euglobin clot lysis time (ELT) were studied in albino rabbits 2. Tolmetin (10 mg/kg), (P.O.) produced marked and significant hypoglycaemic, hypocholesterolaemic and hypouricaemic effects which started after one hour with a peak effect at two hours without complete recovery even upto four hours. 3. It decreased coagulation time and platelet count but increased plasma fibrinogen level and ELT.
[ABSTRACT]   Full text not available  [PDF]
  1,138 88 -
Lack of effect of paracetamol on the pharmacokinetics of chloramphenicol in the adult human subjects
Rajpurohit Ramesh, K Krishnaswamy
July-September 1984, 16(3):124-128
Full text not available  [PDF]
  1,064 123 -
LETTER
Effects of single dose versus serial administration of antivenom serum on coagulation defects in snake bite
RK Saini, S Singh, S Sharma, VK Gupta
July-September 1984, 16(3):170-171
Full text not available  [PDF]
  984 117 -
Excretory pattern of ampicillin in healthy human volunteers
AM Deshpande, SM Doifode, AW Patil
July-September 1984, 16(3):172-172
Full text not available  [PDF]
  879 71 -
Dexamethasone induced leucocytosis in rabbits: possible involvement of catecholamines
VK Srivastava, AK Agarwal, PB Jaju
July-September 1984, 16(3):164-165
Full text not available  [PDF]
  858 66 -
Effect of metoprolol on cardiovascular and respiratory parameters in healthy male subjects
K Kohli, RK Raina, AK Sadhoo
July-September 1984, 16(3):168-169
Full text not available  [PDF]
  809 96 -
Isoniazid inactivation status in tuberculosis patients
K Kohli, RK Raina, RK Zutshi
July-September 1984, 16(3):173-173
Full text not available  [PDF]
  823 77 -
A study of neuromuscular blocking activity of lignocaine and its two analogues
KC Misra
July-September 1984, 16(3):166-167
Full text not available  [PDF]
  709 73 -
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