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   1979| April-June  | Volume 11 | Issue 2  
 
 
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SHORT COMMUNICATION
Effect of essential oils of rhizomes of Hedychium coronarium and Hedychium spicatum on central nervous system :
VK Dixit, KC Varma
April-June 1979, 11(2):147-149
. Pharmacological investigations of the essential oils of rhizomes of Hedychium coronarium and Hedychium specatum reveal that these oils possess mild tranquillizing action of short duration. They depressed the conditioned avoidance response, rotarod performace and potentiated the pentobarbitone hypnosis and morphine analgesia in rats.
[ABSTRACT]   Full text not available  [PDF]
  2,664 341 -
The anti-histaminic activity of (+)-cyanidanol-3 on isolated guinea pig ileum
S Ramaswamy, Pillai N Padmanabha, NS Parmar
April-June 1979, 11(2):135-138
(+)-Cyanidanol-3 was tested for its in vitro antihistaminic activity on isolated guineapig ileum. It inhibited histamine induced contractions without affecting those of acetylcholine, 5-hydro-xytryptamine and potassium chloride. It is concluded that (+)-Cyanidanol-3 produces a relatively specific antihistaminic activity which may be mediated through H1-and H2-receptors.
[ABSTRACT]   Full text not available  [PDF]
  1,725 156 -
RESEARCH PAPER
Biochemical changes in the rat uterine tissue following Embelia ribes burm. extracts
AO Prakash, R Mathur
April-June 1979, 11(2):127-134
. Changes i n the biochemical parameters like glycogen, proteins, nonprotein nitrogen and total solid matter in the uterine tissue of virgin rats have been studied following treatment with 50% ethanol and benzene extracts of Embella ribes Burm. Both the extracts increase significantly the glycogen. protein and nonprotein nitrogen contents in the uterus of normal and ovariectomized rats. The effect depends upon the dose and the period of treatment. Activity is statistically significant at low dose level but decreases as the dose is increased. Higher dose of benzene extract is toxic. Of the extracts, 50% ethanol show encouraging results. Effect is more pronounced in ovariectomized rats than in normal rats.
[ABSTRACT]   Full text not available  [PDF]
  1,537 204 -
Anti-ulcerogenic activity of ayurvedic preparation Taramanduram a preliminary study
NR Pillai, C Seshadri, G Santhakumari
April-June 1979, 11(2):93-99
. Taramanduram a compound ayurvedic preparation used for peptic ulcer was investigated for anti ulcerogenic activity against gastric and duodenal ulcer models in rats and guinea pigs. The drug in a large single dose of 480 mg/kg (p.o.) showed significant protection against Shay ulcers. It markedly reduced the incidence of drug induced duodenal lessions. It is neither antisecretory nor antipeptic and hence the anti-ulcerogenic effect may be due to some no specific activity.
[ABSTRACT]   Full text not available  [PDF]
  1,322 242 -
SHORT COMMUNICATION
Antihistaminic activity of 2-substituted pyrazinopyridoindoles:
GK Patnaik, PC Jain, PK Das, BN Dhawan
April-June 1979, 11(2):139-142
Thirty-nine compounds belonging to a series of 2-substituted pyrazinopyridoindoles were screened for their antihistaminic activity on the isolated guineapig ileum preparation. All the compounds showed a specific antihistaminic activity of varying degree. Their SAR is discussed.
[ABSTRACT]   Full text not available  [PDF]
  1,310 143 -
RESEARCH PAPER
Effect of L-dopa on copulatory behaviour in rats
BV Venkataraman, Joseph Thangam
April-June 1979, 11(2):119-125
. The effect of L-dopa on copulatory behaviour was studied in sexually receptive female rats and sexually trained male rats. L-dopa 100 mg/Kg inhibited the copulatory behaviour in female rats. They showed rejections and exhibited no lordosis when males attempted to mount. The same animals on treatment with normal saline a week earlier or later accepted the males without any rejection and showed different grades of lordosis as an index of acceptance. Haloperidol 75 'g/rat given prior to L-dopa reversed the inhibition of female copulatory behaviour produced by L-dopa. L-dopa 100 mg/kg did not alter the male copulatory behaviour either in normal copulators or sexually sluggish males.
[ABSTRACT]   Full text not available  [PDF]
  1,315 88 -
SHORT COMMUNICATION
Salivary excretion of orally administered radio-iodine
VS Gokhale, SD Harshe, RD Kulkarni
April-June 1979, 11(2):151-153
. Radioactive-iodine (I131) was administered to twelve normal healthy volunteers in a doss of ten microcuries before and after thyroxine/iodine therapy. Salivary excretion at 30 minutes and thyroid uptake. at 2 hours and at 24 hours after administration of 1131 were measured and com-pared. The results show that the salivary excretion of iodine does not seem to depend on TSH.
[ABSTRACT]   Full text not available  [PDF]
  1,205 92 -
Inhibitory effect of thiabendazole on isolated guinea pig ileum against different agonists
Pillai N Padmanabha, S Ramaswamy, CH Shashindran, MN Ghosh
April-June 1979, 11(2):143-146
. Thiabendazole when incubated (in vitro) for 5 min produced a dose dependent inhibition of Ach responses in guineapig isolated ileum preparation. In lower concentrations (500 ng) the inhibition produced by thiabendazole is relatively specific to histamine and acetylcholine, whereas in higher concentration (5 (g) a nonspecific inhibition of the responses of histamine, ACh. 5-hydroxytryptamine and potassium chloride was observed.
[ABSTRACT]   Full text not available  [PDF]
  1,151 86 -
RESEARCH PAPER
Antihistaminic activity of 4-fluoro-3-(1-piperidyl)propiophenon-a centrally acting skeletal muscle relaxant
GK Patnaik, M Sabir, BN Dhawan
April-June 1979, 11(2):107-111
. In concentration of 0.1-I(g/ml, compound 4-fluoro-3-(l-piperidyl) propiophenone produce+ dose dependent reversible inhibition of the spasmogenic effect of histamine on isolated guinea-pig ileum without altering its response to acetylcholine, 5 -hydroxytryptamine, incotine and KCI. On the isolated guineapig atria 2 (g/ml of the compound inhibited the positive chronotropic and inotropic effect of both histamine and adrenaline In doses of 2.5-10 mg/kg it reduced by about 80%, the hypotension induced by histamine but not that by acetylcholine or isopranalino in anaesthetised cat. The inhibitory effect lasted for 40.70 min. In the Konzett-Rossler preparation of guinea-pig, it (1mg/kg) blocked the broncho constriction induced by histamine without altering that by acetylcholine, It also protected the guineapigs from histamine induced bronchospasm as well as death due to intravenously administered histamine.
[ABSTRACT]   Full text not available  [PDF]
  1,089 128 -
SHORT COMMUNICATION
Teaching of pharmacology by self-instruction a pilot study
GJS Abraham, VG Dhume, RS Diniz
April-June 1979, 11(2):155-157
. A pilot study was undertaken to evaluate teaching of pharmacology by self learning (instruction) in comparison) with teaching by lectures. Though the performance in the examination indicates that it is equally effective, students expressed preference to didactic lectures.
[ABSTRACT]   Full text not available  [PDF]
  1,113 92 -
RESEARCH PAPER
In vitro effects of cyclic AMP, L-dopa and 6-hydroxydopamine on rat brain dopamine - beta - hydroxylase
Srivastava Madhulika, NK Kapoor
April-June 1979, 11(2):113-118
. Dopamine-f-hydroxylase (DBH activity of rat brain was found to be stimulated by cyclic tand L- DOPA. The stimulation of enzyme activity increased with increasing concentration of the activators. 6 -hydroxydopamine (6-OHDA) caused an inhibition of brain DBH activity which may be due to the degeneration of adrenergic neurons. .The inhibitory effect was partially prevented in presence of cAMP or GDOPA.
[ABSTRACT]   Full text not available  [PDF]
  1,114 81 -
RESEARCH PAPER
Evidence for a neurogenic mechanism in dopamine induced depressor response in the anesthetized dog
MF Lokhandwala
April-June 1979, 11(2):101-105
. Intravenous administration of dopamine (0.5 to 8.0 'g/kg) to pentobarbital anesthetized dogs resulted in decreases in arterial blood pressure with no significant alterations in heart rate. This depressor action of dopamine was reversed into a pressor action after pretreatment with hexamethonium plus atropine. Dopamine again produced a depressor response in these animals after administration of phentolamine. Haloperidol pretreatment significantly attenuated this depressor effect of dopamine observed in ganglion blocked, phentolamine treated animals. These results demonstrate that the initial vasodepressor action of dopamine involves a neurogenic mechanism which may include activation of either the ganglionic and/or presynaptic dopamine receptors.
[ABSTRACT]   Full text not available  [PDF]
  1,065 70 -
REVIEW ARTICLE
Guanethidine induced sympathectomy
PDMV Turlapaty, S Jayasundar, MN Ghosh
April-June 1979, 11(2):87-92
Full text not available  [PDF]
  861 84 -
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