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   1976| April-June  | Volume 8 | Issue 2  
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The effect of Luffa echinata in liver injury
P Lauria, VN Sharma, S Vanjani, BC Sangal
April-June 1976, 8(2):129-133
The ether and alcohol extracts of Luffs echinata. known as Devadali (family cucurbitaceae) offered definite protection against experimentally induced liver injury by Ccl. in albino rats. The ether extract was more effective than the alcohol extract.
[ABSTRACT]   Full text not available  [PDF]
  2,144 333 -
Effects of proteins of Cassia marginata, Cassia renigera and Cassia obstusifolia wild leguminous seeds on blood and liver cholesterol in young albino rats
KN Singh, V Chandra, KC Barthwal
April-June 1976, 8(2):149-152
Wild leguminous seed proteins of Cassia marginata, Cassia renigera and Cassia obstusifolia were investigated for their effects on blood and liver cholesterol levels in young albino rats. They were found to have a marked lowering effect on blood and liver cholesterol levels. It is suggested that these effect are probably due to direct or indirect inhibition of cholesterol synthesis in the liver.
[ABSTRACT]   Full text not available  [PDF]
  2,101 139 -
Studies on anti-hyperglycaemic effect of onion (Allium cepa Linn) : Some observations on the mechanism of its antihyperglycaemic effect in man-A preliminary report
Gupta Sushma, KK Sharma, RK Gupta
April-June 1976, 8(2):153-155
A possible mechanism of the antihyperglycaemic effect of onlon in man is discussed. Probably it affects the metabolism of glucose by reducing the rats of glucogenolysis and neo-glucogenesis in liver.
[ABSTRACT]   Full text not available  [PDF]
  1,604 169 -
Effect of intravenous infusion of calcium chloride on sheep ECG
BS Paul
April-June 1976, 8(2):135-140
The effect of intravenous infusion of 6% calciumchloride on the E. C. G. of sheep, both during and after stopping the administration has been studied. There was significant increase in heart rate at serum calcium levels of 22.35Ort4.365 mg per cent and its intensity increased with the dose. The QT interval and ST segment were shortened significantly while the prolongation of PR interval and QRS complex was insignificant. The amplitudes of R and T waves were increased and it was significant only for the latter at swum calcium levels of 22.350(4.365 to 27.600(5.555 mg %. The infusion of calcium chloride also resulted in various types of arrhythmias viz. sinus arrhythmia with bradycardia and atrio-ventricular blocks.The animals showed laboured respiration and restlessness during infusion and showed tachycardia with disturbed rhythm of premature beats and atrio-ventricular blocks for 2-4 hours after stopping the infusion.There were also delayed deaths.
[ABSTRACT]   Full text not available  [PDF]
  1,577 116 -
Role of brain monoamines in pentylenetetrazol convulsions In mice
SK Bhattacharya
April-June 1976, 8(2):141-144
The role of brain dopamine in pentylenetetrazol (PTZ) induced clonic convulsions in albino mice was investigated by using drugs which selectively raise brain dopamine levels. dopamine receptor agonists and antagonists.PTZ convulsions were potenliated by drug treatments which selectively increase brain concentrations of dopamine and by dopamine receptor agonists, apomorphine and amphetamine. Haloperidol, a selective dopamine receptor antagonist. inhibited PTZ convulsions and apomorphine or amphetamine induced potentiation of PTZ. The results suggest that dopamine may have a role in PTZ induced clonic convulsions in mice.
[ABSTRACT]   Full text not available  [PDF]
  1,407 130 -
Role of magnesium sulphate in experimentally induced cardiac arrhythmias in dogs
KC Kotia, Khalsa Amrit, SK Naveen, SS Haldia
April-June 1976, 8(2):125-128
Intravenous magnesium sulphate has been found to be effective in either correcting or preventing the various ventricular arrhythmias and atrial fibrillation, while its effect in atrial flutter is noted to be poor in experimentally induced arrhythmias in dogs.
[ABSTRACT]   Full text not available  [PDF]
  1,431 91 -
Modification of CNS excitatory activity of d-amphetamine by a-a-dipyridyl and reserpine in rats
P Lauria, VN Sharma, OP Mangal
April-June 1976, 8(2):119-123
The ambulation and rearing activities were tested on 'open field' in rats treated with amphetamine alone and in combination with ( -(-dipyridyl (DDP) and reserpine. The excitatory response of amphetamine in a doss of 2 mg/kg was not observed in rats pretreated with DDP or reserpine. Though the depressed activity in reserpinised rats was significantly antagonised by amphetamine, the values were still lower (P<0.001) than the control values. The data revealed the role of continuous norepinephrine synthesis in amphetamine excitatory response besides its release from the stores. The present work also indicates that dopamine is not directly responsible for amphetamine induced locomotor or stereotyped activity nor doer amphetamine stimulates adrenergic receptors directly to produce the excitatory response.
[ABSTRACT]   Full text not available  [PDF]
  1,329 90 -
Modification of morphine analgesia by sulphonamides
SV Kanitkar, VS Gokhale, SD Kulkarni, GV Joglekar
April-June 1976, 8(2):145-147
Modification of morphine analgesia by pretreatment with sulphapyridine. sulphadiazine. sulphacetamide and sulphamathoxypyridazine has been studied in mice using the tail clip method. The possible role of protein binding in these interactions has been discussed.
[ABSTRACT]   Full text not available  [PDF]
  1,280 76 -
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