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   1975| October-December  | Volume 7 | Issue 4  
 
 
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RESEARCH PAPER
Studies on the pharmacological effects of extracts and total alkaloids of Tylophora indica
R Dhananjayan, C Gopalakrishnan, L Kameswaran
October-December 1975, 7(4):13-20
An alcoholic extract and the total alkaloids obtained from the leaves of the plant Tylophora lndica were studied for their pharmacological effects on various intact and isolated biological preparations. On the CNS, the extract and the total alkaloids produce depression in near lethal doses. On the CVS, the extract and the total alkaloids produce myocardial depression and fall of blood pressure in relatively large doses. On smooth muscles such as the ileum, uterus and tracheal ring chain of guinea pigs. rats and dogs, the drugs produce non-specific relaxation. The Contractile effects of histamine, acetylcholine and posterior pituitory extract are antagonised. The total alkaloids at a dose of 10 mg/kg (orally) prolong the survival rate of skin homografts in rats and increase the weight of adrenal glands.The probable mode of action in bronchial asthma is discussed.
[ABSTRACT]   Full text not available  [PDF]
  2,146 501 -
SHORT COMMUNICATION
Central nervous system depressant activity of Ipomea carnea jacq
SK Bhattacharya, AB Ray, B Dasgupta
October-December 1975, 7(4):31-34
Pharmacological studies conducted with the non-alkaloidal and non-saponifiable fraction isolated from the leaves of Ipomea carnea Jacq.. demonstrate the depressant action of the drug on the central nervous system Tranquilizing activity was absent and the drug appears to fall under the sedative-hypnotic category of central depressants with muscle relaxant property.
[ABSTRACT]   Full text not available  [PDF]
  1,834 238 -
RESEARCH PAPER
Screening of metal complexes for biological activity: Part I. Pharmacological investigations of some cobalt (II) oxalate complexes with substituted pyridines and quinoline.
SK Bajpai, PR Shukla
October-December 1975, 7(4):21-25
Same oxalatoamine cobalt (II) complexes of the general formula COC2O4 (am), nH20 were prepared with a view to study their pharmacological activities. Compounds No. 1. 3 and 4 showed depressant effect on CNS, whereas compounds No. 5 and 6 were stimulants. Compounds No. 1, 2. 3 and 5. however. Possessed weak anti-inflammatory activity, whereas compounds No. 2 and 4 exhibited pronounced antipassive cutaneous anaphylaxis activity, The compounds studied neither showed any significant effect on CVS nor did they exhibit anti-arrhythmic and diuretic activity.
[ABSTRACT]   Full text not available  [PDF]
  1,311 139 -
A study of the open field behaviour as a single parameter
PC Dandiya, SK Kulkarni
October-December 1975, 7(4):1-4
In order to estimate the Open Field Behaviour (OFB) is a single numerical data. the ambulatory and rearing response due to a large number of central nervous System active agents was compared with standard normal activity and OFB value was calculated for each agent studied. The OFB values of each drug were graphically plotted against the respetive log ratio of ambulation and rearing scores. An attempt has been made to regroup these agents.
[ABSTRACT]   Full text not available  [PDF]
  1,163 130 -
SHORT COMMUNICATION
Effects of potassium on electrocardiographic and serum electrolyte changes induced by chlorpromazine and GO-3315 in experimental animals
KC Kotia, OP Garg, Khalsa Amrit, RK Joshi
October-December 1975, 7(4):39-44
The present study incorporates the effects of potassium chloride on various electrocardiographic end serum electrolyte changes produced by chlorpromazine and GO-3315. Both the drugs when administered with potassium, increase the P R and Q R S interval while decrease the QT interval. Abnormal ventricular complexes do not occur when both the drugs are given with potassium in contrast t o the drugs when given alone. Both the drugs have insignificant affect on serum Na+, Cl- and Ca++ but decrease the serum K+ levels.
[ABSTRACT]   Full text not available  [PDF]
  1,157 103 -
RESEARCH PAPER
Effect of adrenergic blockade on adrenaline induced pulmonary edema in mice
C Jayachandran, P Murty
October-December 1975, 7(4):5-11
The effect of adrenergic blockade on adrenaline induced pulmonary edema was studied on mice by using specific adrenergic blockers. The results showed that alpha blockade did not show significant effect on adrenaline induced pulmonary edema (A.P.E.) whereas beta blockade prevented A.P.E. in mice. The effect of combined alpha and beta blockade on A.P.E was not significant and the reason for this has to be sought further. The study showed that beta adrenergic receptor seems to have a role in production of A.P.E. in mice.
[ABSTRACT]   Full text not available  [PDF]
  1,162 86 -
SHORT COMMUNICATION
A double blind clinical study of prenylamine lactate in the cases of ischaemic heart disease
KC Kotia, Khalsa Amrit, Swaroop Dinesh, OP Garg, DS Pokharana
October-December 1975, 7(4):27-30
In the present double-blind trial, 25 cares received prenylamine and 26 cases placebo. The patients were observed for 6 weeks before institution of therapy and for another 6 weeks during therapy. Clinical as well as electrocardiographic assessment was done. There was improvement in frequency and severity of anginal attacks and the consumption of GTN tablets in both groups decreased. But this improvement was highly significant in prenylamine serieses compared to placebo. Electrocardiographic improvement was also more marked with prenylamine than with placebo. The side effects were even less marked in prenylamine series. Hence it is concluded that patients of angina pectoris are more benefitted with prenylamine than with placebo.
[ABSTRACT]   Full text not available  [PDF]
  1,114 77 -
Role of 5-hydroxytryptamine in hexobarbitone induced hypnosis in albino rats and mice
SK Bhattacharya, PK Debnath, SM Mukhopadhyay, PK Das
October-December 1975, 7(4):35-38
The role of 5-hydroxytryptamine (5HT) in hexobarbitone hypnosis has been investigated in albino rats and mice, by employing drugs, with well documented effects on 5HT turnover in brain and noting their interactions with hexobarbitone. 5HT synthesis inhibitor. p-chlorophenylalanine, end methysergide, a specific tryptaminargic receptor antagonist, inhibited hexobarbitone hypnosis and nialamide induced potentiation of hexobarbitone in rats but not in mice. The 5HT precursor, 5HTP, potentiated hexobarbitone action Only in rats and this potentiation was blocked by methysergide. The results indicate that hexobarbitone induced sleep in rats is 5HT mediated, while the same is not true in mice.
[ABSTRACT]   Full text not available  [PDF]
  1,115 70 -
REVIEW ARTICLE
Presenting papers: methods and forms
PC Dandiya, HL Sharma
October-December 1975, 7(4):47-50
The role of 5-hydroxytryptamine (5HT) in hexobarbitone hypnosis has been investigated in albino rats and mice, by employing drugs, with well documented effects on 5HT turnover in brain and noting their interactions with hexobarbitone. 5HT synthesis inhibitor. p-chlorophenylalanine, end methysergide, a specific tryptaminargic receptor antagonist, inhibited hexobarbitone hypnosis and nialamide induced potentiation of hexobarbitone in rats but not in mice. The 5HT precursor, 5HTP, potentiated hexobarbitone action Only in rats and this potentiation was blocked by methysergide. The results indicate that hexobarbitone induced sleep in rats is 5HT mediated, while the same is not true in mice.
[ABSTRACT]   Full text not available  [PDF]
  984 100 -
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