1. Twenty five Mannich bases of para substituted acetophenones were synthesized and tested for local anaesthetic activity in rabbits and guineapigs. 2 All the compounds of dibenzyl series showed significant surface and infiltration anaesthetic activity. 3. In the piperidine series only compound (-piperidinoethyl p-chlorophenyl ketone HCI showed local anaesthetic activity. This compound did not possess any local irritant effect.

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1. Pain threshold for thermal stimulus after different doses of indomethacin and paracetamol was determined in male and female rats before and after three days treatment with testosterone. It was also determined 15 days after gonadectomy. 2. There was a significant reduction in analgesia induced by indomethacin as well as paracetamol after testosterone administration to rats. 3. There was a marked reduction in analgesia induced by these drugs if the rats are gonadectomised and naloxone enhanced the indomethacin and paracetamol induced analgesia.

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1. The present study was undertaken to compare the possible anti-anaphylactic, anti- histaminic and anti-bradykinin activities of chloroquine, aspirin and indomethacin with those of prednisolone. 2. Chloroquine and prednisolone protected animals in all the parameters used in our study but aspirin and indomethacin, did not afford animals any protection against systemic anaphylaxis and histamine toxicity but enhanced the histamine and bradykinin effects in vitro.

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1. The effect of various ecbolics was studied on isolated human myometrial strips obtained at caesarian section from normal and high risk pregnancy cases. 2. Oxytocin was found to be the most potent ecbolic and acetylcholine the least active. The activity of the other agents tested was PGEI>PGE >PGF -(>ergometrine>histamine >serotonin. 3. Further a possibility of greater sensitivity of uterus to oxytocin in the pre-oclamptic toxaemia and bad obstretic cases was indicated, it also appeared that with decreased ratio between the serum progesterone and oestradiol, within a particular group of patients, the myometrium was found to be more sensitive to oxytocin.

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1. The effect of non-steroidal anti-inflammatory agents like aspirin, tromaril and tolmetin on tolbutamide-induced hypoglycaemia in normal and alloxan-induced diabetic rabbits was studied. In order to evaluate the mechanism of interaction the effect of non-steroidal anti-inflammatory agents was also observed on the blood glucose level aswell as on serum tolbutamide concentration. 2. Single dose concurrent administration and 7 days continued treatment with aspirin and tolmetin enhanced tolbutamide-induced hypoglycaemia. However, a decrease in serum tolbutamide level was observed when given concurrently with single dose of anti-inflammatory drugs. Tromaril failed to affect tolbutamide hypoglycaemia and serum concentration of tolbutamide both in normal as well as in diabetic rabbits. 3. It is reasonable to conclude that aspirin and tolmetin possess interacting potentiality probably by virtue of their intrinsic hypoglycaemic activity and plasma protein binding property.

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1. Effect of ethinyl estradiol (Lynoral) on 3H-spiroperidol binding has been studied in hypothalamic and corpus striatal regions of the brain after acute and subchronic exposure. 2 Ethinyl estradiol (10(g/kg) after 3 consecutive doses (acute) showed significant increase in 3H-spiroperidol) binding only in hypothalamic membrane without affecting the corpus striatal membrane. 3. A significant increase in 3H-spiroperidol binding was observed in caudate and hypothalamic membrane in the animals exposed to same dose of estradiol for 21 consecutive days (subchronic). 4. The results suggest that ethinyl estradiol effects dopamine receptor sensitivity in brain regions.

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1. Propranolol ( 5O, 100 and 200, (M) produced a dose related inhibition of platelet aggregation induced by ADP (3(M) and adrenaline (16(M). 2. Timolol upto a concentration of 200 (M had no significant effect on either model of aggregation. 3. Propranolol also significantly inhibited the rat paw oedema induced by carrageenan. 4. It is inferred that propranolol has an anti-platelet aggregatory effect which is unrelated to beta adrenoceptor blockade and could be due an anti-prostaglandin effect of the drug.

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(1) The influence of various antitubercular drugs either alone or in combination on hexobarbitone metabolism was studied in mice by observing its sleeping time. (2) Ethambutol and pyrazinamide did not affect the hexobarbitone sleeping time. (3) isoniazid alone and in combination with pyrazinamide significantly increased, while rifampicin (7 days administration) alone and in combination with other antitubercular drugs used decreased hexobarbitone sleeping time.

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1. The effect of B. pertussis vaccine a hypoglycemic agent, was studied on the morphology of the Beta cells of the pancreas in rabbits. 2. The vaccine did not lower the blood sugar in alloxan induced diabetic animals. 3. When administered four days prior to the injection of alloxan, it protected the beta cells from the destructive changes produced by the toxic agent.

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1. In 33 epileptic patients on phenytoin monotherapy. the CSF levels of the drug constituted 12.5( 5% (range 5.4 to 23%) of the serum levels. 2. The mean serum levels of the drug (13.356 (g/ml) in controlled patients (17) were not significantly different from the levels in uncontrolled patients (11). The mean CSF levels in uncontrolled patients (0.92(O.32) were significantly lower (p<0.001) than those in controlled patients (1.49(0.59). 3. In 5 patients who developed toxicity, the serum (27.3 ( 10.6) as well CSF (5.3 ( 1.8) levels of phenytoin were significantly higher than those of uncontrolled and controlled (without toxicity) patients.

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1. Penbutolol, a new, centrally-active (-blocking agent has been studied for its interaction with alcohol. 2. Alcohol (75(proof whisky) as 0.8 mg/kg was administered with 20 mg. penbutolol or placebo in double-blind crossover to 6 volunteers. 3. Psychomotor tests of performance did not reveal any significant penbutolol-alcohol interaction. 4. Peak changes in psychomotor performance coincided under both treatment conditions with peak serum alcohol levels.

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