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Access statistics : Table of Contents
1969| October-December | Volume 1 | Issue 4
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REVIEW ARTICLE
Preclinical safety evaluation of new drugs
RR Rao
October-December 1969, 1(4):1-13
Full text not available
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1,596
431
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RESEARCH PAPER
Synthesis of quinazolone arylalkyl hydrazines: role of quinazolone ring substitution on the monoamine oxidase inhibitory activity
SS Parmar, RC Arora, JP Barthwal
October-December 1969, 1(4):37-49
Full text not available
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1,656
240
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RESEARCH PAPER
Central antiserotonin activity of certain antihistaminics
SK Bapat, Chandra Vimal
October-December 1969, 1(4):32-36
The central 5-HT antagonist activity of 5 newer antihistaminics (chlorprothixene, chlorpentixol, diphenylpyraline, cyproheptadine, and mebhydrolin) has been studied and all of them have been found to possess central anti - 5-HT activity. These drugs have also been screened by the metrazol threshold test and all the five have been found to increase the toxicity of metrazol. A possible correlation between potentiation of metrazol toxicity and central anti-5-HT activity of these drugs has been discussed. It has been suggested that these drugs should be avoided or be given with caution while treating the patients of petit mal epilepsy for allergic manifestations.
[ABSTRACT]
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A comparison of the experimental methods for screening of anti-inflammatory activity
MB Gupta, KK Tabgrum, GP Gupta, KP Bhargava
October-December 1969, 1(4):24-31
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1,266
405
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Effect of reserpine pretreatment on barbiturate sleeping time and brain barbiturate concentration in rats
H Vimala, Sethy, SR Naik, UK Sheth
October-December 1969, 1(4):14-18
Full text not available
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1,514
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Interaction of morphine and dopamine on some smooth muscles
JN Sharma, BN Dhawan, KN Dhawan
October-December 1969, 1(4):50-52
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1,208
132
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Studies on a potential anti-ulcer compound b-N-di-n propyl aminoethyl-o-methoxoy phenylether hydrochloride
GB Singh, NM Khanna, AP Bhaduri
October-December 1969, 1(4):19-23
Full text not available
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1,045
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