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2002| May-June | Volume 34 | Issue 3
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SHORT COMMUNICATION
Immunostimulant activity of Ashtamangal ghrita in rats
Fulzele, AK Dorle, PM Bhurchandi, VM Kanoje, SB Joshi
May-June 2002, 34(3):194-197
1. A series of 9-alkylamino-1, 2, 3, 4-tetrahydroacridines and analogues were synthesized and tested for local ansesthetic activity in rabbits and guinea pigs. 2. 9-n-Heptylamino-1, 2, 3, 4-tetrahydroacridines showed the maximum activity and were more potent than lignocaine. 3. The local anaesthetic activity seems to be partly influenced by the lipophilicity of the compounds.
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RESEARCH PAPER
Improvement of insulin sensitivity by perindopril in spontaneously hypertensive and streptozotocin-diabetic rats
G Shenoy Arun, K Goyal Ramesh
May-June 2002, 34(3):156-164
Objective: To investigate the direct and the indirect effects of flt3 ligand (FL) on hematopoiesis. Methods: Mononuclear cells from human cord blood were plated in methylcellulose medium containing different cytokines for inducing hematopoietic colony formation. Dendritic cells were induced from the mononuclear cells with a cytokine cocktail with or without recombinant human soluble FL (rhFL; 100ng/ ml). The flt3 receptors on the surface of a human microvascular endothelial cell line (ECV) were analyzed by flow cytometry. The proliferation of ECV stimulated by FL was measured with the microculture tetrazolium assay. We also measured the level of FL in the supernatant of ECV cultures. Results: RhFL stimulates colony formation from cord blood when used as sole stimulant. FL in combination with other cytokines increased colony formation significantly. The number of DC was approximately 2.5 times higher when rhFL was used. RhFL stimulates the proliferation of ECV on which flt3 receptors is expressed. Furthermore, ECV secretes FL and this effect is augmented by tumor necrosis factor-?(?(TNF( ) and reduced by glucocorticoid. Conclusions: FL enhances hematopoietic colony formation and DC proliferation from human cord blood cells. FL not only stimulates the proliferation of ECV, but it is also secreted by ECV. It appears that FL may act as an autocrine growth cytokine of endothelial cells.
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EDITORIAL
Pharmacogenomics: "The right drug for the right person"
C Adithan
May-June 2002, 34(3):155-155
1. In the present study it has been shown that acetylsalicylic acid (ASA) produces hemolysis of both normal and G-6-PD deficient erythrocytes. 2. The degree of hemolysis is almost the same in both the erythrocytes. 3. Acetylation and peroxidation of membrane lipid do not appear to be necessary for the hemolytic effect of ASA. 4. Severe membrane damage as evident from the liberation of phospholipids and sterols appears to be the mechanism by which ASA produces hemolysis.
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SHORT COMMUNICATION
The antinociceptive and antiinflammatory activities and lack of ulcerogenicity of a benzodioxin-4-one and its analog benzoxazine as cyclic acetal-like derivatives of salicylic acid and salicylamide in mice and rats
Khalaj Ali, Abdollahi Mohammad, Kebriaeezadeh Abbas, Adibpour Neda, Pandi Zahra, Rasoulamini Sara
May-June 2002, 34(3):184-188
1. In the present study it has been shown that acetylsalicylic acid (ASA) produces hemolysis of both normal and G-6-PD deficient erythrocytes. 2. The degree of hemolysis is almost the same in both the erythrocytes. 3. Acetylation and peroxidation of membrane lipid do not appear to be necessary for the hemolytic effect of ASA. 4. Severe membrane damage as evident from the liberation of phospholipids and sterols appears to be the mechanism by which ASA produces hemolysis.
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LETTER
Depressant effect of tramadol on frog heart
CS Gautam, PK Sharma, NK Goel
May-June 2002, 34(3):202-203
1. A series of 9-alkylamino-1, 2, 3, 4-tetrahydroacridines and analogues were synthesized and tested for local ansesthetic activity in rabbits and guinea pigs. 2. 9-n-Heptylamino-1, 2, 3, 4-tetrahydroacridines showed the maximum activity and were more potent than lignocaine. 3. The local anaesthetic activity seems to be partly influenced by the lipophilicity of the compounds.
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SHORT COMMUNICATION
Pharmacology of anti-epileptic drugs: A computer aided teaching module and its evaluation in medical undergraduates
A Viswanathan, D Xavier, C Kulkarni
May-June 2002, 34(3):178-183
1. In the present study it has been shown that acetylsalicylic acid (ASA) produces hemolysis of both normal and G-6-PD deficient erythrocytes. 2. The degree of hemolysis is almost the same in both the erythrocytes. 3. Acetylation and peroxidation of membrane lipid do not appear to be necessary for the hemolytic effect of ASA. 4. Severe membrane damage as evident from the liberation of phospholipids and sterols appears to be the mechanism by which ASA produces hemolysis.
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The effect of captopril, prazosin and methyldopa on atherosclerotic plaque formation in hypercholesterolaemic rabbits
Husaini Fallah, M Manusuri Saber, Haghighi M Kavoli
May-June 2002, 34(3):198-201
1. A series of 9-alkylamino-1, 2, 3, 4-tetrahydroacridines and analogues were synthesized and tested for local ansesthetic activity in rabbits and guinea pigs. 2. 9-n-Heptylamino-1, 2, 3, 4-tetrahydroacridines showed the maximum activity and were more potent than lignocaine. 3. The local anaesthetic activity seems to be partly influenced by the lipophilicity of the compounds.
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Interaction between H2-receptor blocker and neuromuscular blockers in vitro
CB Tripathi, JD Bhatt, UD Panchakshari, KG Hemavathi, OD Gulati
May-June 2002, 34(3):189-193
1. A series of 9-alkylamino-1, 2, 3, 4-tetrahydroacridines and analogues were synthesized and tested for local ansesthetic activity in rabbits and guinea pigs. 2. 9-n-Heptylamino-1, 2, 3, 4-tetrahydroacridines showed the maximum activity and were more potent than lignocaine. 3. The local anaesthetic activity seems to be partly influenced by the lipophilicity of the compounds.
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RESEARCH PAPER
Flumazenil prevents the suppression of rat submandibular gland function by benzodiazepines
Abdollahi Mohammad, Rahbar Haghighat Maasoumeh, SoltaninejAD Kambiz
May-June 2002, 34(3):165-171
1. In the present study it has been shown that acetylsalicylic acid (ASA) produces hemolysis of both normal and G-6-PD deficient erythrocytes. 2. The degree of hemolysis is almost the same in both the erythrocytes. 3. Acetylation and peroxidation of membrane lipid do not appear to be necessary for the hemolytic effect of ASA. 4. Severe membrane damage as evident from the liberation of phospholipids and sterols appears to be the mechanism by which ASA produces hemolysis.
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CORRESPONDENCE
Voluntary adverse drug reaction reporting in a tertiary care teaching hospital
DC Dhasmana, Seth Vikas, KC Misra
May-June 2002, 34(3):204-205
1. A series of 9-alkylamino-1, 2, 3, 4-tetrahydroacridines and analogues were synthesized and tested for local ansesthetic activity in rabbits and guinea pigs. 2. 9-n-Heptylamino-1, 2, 3, 4-tetrahydroacridines showed the maximum activity and were more potent than lignocaine. 3. The local anaesthetic activity seems to be partly influenced by the lipophilicity of the compounds.
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RESEARCH PAPER
Enhanced regression of tumors in mice with combined chemotherapy and immunotherapy
K Srikanth, Debnath Bikash, Jha Tharun, Sankar Nayak Siva
May-June 2002, 34(3):172-177
1. In the present study it has been shown that acetylsalicylic acid (ASA) produces hemolysis of both normal and G-6-PD deficient erythrocytes. 2. The degree of hemolysis is almost the same in both the erythrocytes. 3. Acetylation and peroxidation of membrane lipid do not appear to be necessary for the hemolytic effect of ASA. 4. Severe membrane damage as evident from the liberation of phospholipids and sterols appears to be the mechanism by which ASA produces hemolysis.
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MOLECULES OF THE MILLENNIUM
Newer drugs used in colorectal carcinoma
N Subramanian, R Balaraman
May-June 2002, 34(3):206-207
1. A series of 9-alkylamino-1, 2, 3, 4-tetrahydroacridines and analogues were synthesized and tested for local ansesthetic activity in rabbits and guinea pigs. 2. 9-n-Heptylamino-1, 2, 3, 4-tetrahydroacridines showed the maximum activity and were more potent than lignocaine. 3. The local anaesthetic activity seems to be partly influenced by the lipophilicity of the compounds.
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CONFERENCE ABSTRACTS
XXXIV annual conference of the Indian pharmacological society, Nagpur, January 10-12, 2002 abstracts of research papers (Part-II)
IPS
May-June 2002, 34(3):211-226
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WEB WISE
Nofreelunch
Singh Jatinder
May-June 2002, 34(3):208-209
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CALENDAR REVIEW
Calendar for Pharmacists 2002
DG Shewade
May-June 2002, 34(3):210-210
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