1. Ranitidine, a newly introduced H2 antagonist potentiated the contractile responses of guinea pig ileum to histamine. 2. Histamine could inhibit the contractile responses to acetylcholine when H1 receptors were blocked by pheniramine maleate. 3. When the tone of the guinea pig ileum preparation was increased by continuous superfusion of acetylcholine with HI blocker pheniramine in the perfusate, histamine and dimaprit could produce dose dependent relaxation. This could be blocked by ranitidine. 4. It is suggested that inhibitory-histamine H2 receptors are present in the guinea pig ileum.

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1. The effects of 6 weekly injections of ochratoxin A (5 mg/kg, ip) and citrinin (20 mg/kg. ip) were studied on the following indices of mice: epinephrine, norepinephrine and dopamine in brain and liver and 5- hydroxytryptamine in brain. 2. These mycotoxins resulted in a significant decrease in dopamine and increase in epinephrine, norepinephrine and 5-hydroxytryptamine content of brain. 3.These mycotoxins also resulted in significant increase in epinephrine, norepinephrine and dopamine in liver. 4. The increased concentrations of the neurotransmitters in mouse brain might be associated with CNS depressant action induced by mycotoxins.

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1. Decrease in the activity of glucose 6 phosphate dehydrogenase (G6PDH), sorbitol dehydrogenase (SDH) and NADP has been suggested as a possible cause of cataract formation, via the effects on glycolysis, HMP shunt and sorbitol pathways in galactosemic and other types of cataract 2. In contrast to normal lenses alloxan-induced cataractous lenses showed a decrease in the activities of G 6 PDH and SDH in blood, aqueous humor and lens. 3. The results indicate that aloxan-induced cataract has an inhibitory effect on some of the lenticubr metabolic pathways.

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1. Five antibacterial agents viz. doxycycline, co-trimoxazole, ampicillin, gentamicin and rifampicin were studied for their interaction with glibenclamideon blood sugar level (BSL) in rabbits. 2. All these antibacterial agents failed to induce perse any significant modulation of BSL. 3. In doxycycline treated rabbits glibenclamide induced a greater degree of mean hypoglycemic effect at the end of 1 and 6 h. 4. In rifampicin pretreated rabbits the hypoglycemic effect of glibendamide was significantly delayed and reduced. Ampicillin, gentamicin or cotrimoxazole failed to modify glibenclamide induced hypoglycemia.

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1.The effect of intraperitoneal,administration of indomethacin was studied on antibody titre following im or iv administration of S. typhi 'o' antigen in rabbits. 2. Indomethacin administration caused an increased production of antibodies which was dose related. It appears to act on both IgC and 1gM antibodies and is not associated with any change in total serum proteins and albumin/globulin ratio. 3.The administration of indomethacin like drugs may be beneficial in the development of immune function.

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1. Interaction of chandonium iodide, a new non-depolarizing neuromuscular blocking agent, with intravenous anaesthetic agents like thiopentone, ketamine and etomidate has been studied in cats. 2. The onset and duration of neuromuscular block with chandonium and its reversibility by neostigmine were unaffected by the aneasthetic agents investigated. A signifificandy higher dose of chandonium was required with ketamine to produce 50% block of neuromuscular transmission. 3. Chandonium exhibited atropine like effect on cardiac vagal neuroeffector junction. It had no significant effect on blood pH, pCO2 or pO2 . A significant increase ( P < 0.01) in serum potassium was observed in cats anaesthetised with etomidate prior to administration of chandonium and a significant decrease (P < 0.05) was observed with thiopentone anaesthesia.

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1. The effect of intraperitoneal yohimbine on pain threshold in mice has been investigated. The drug was devoid of any analgesic activity at lower doses (1 mg/kg). However, the pain reactions was modified at 10 mg/kg. 2. Subanalgesic doses of yohimbine prolonged the duration of morphine analgesia. 3. Alteration in the ratio of brain 5 HT : Noradrenaline has been proposed as a possible mechanism for the effects of yohimbine.

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1. Salicylate pharmacokinetic parameters in six healthy and ten worm infested adults were determined after an oral dose of 1200 mg of acetylsalicylic acid. 2. The results obtained indicate that various kinetic values obtained in normal volunteers in the present study are almost similar to the data reported for European and American populations 3. Round worm infection did not alter any aspect of the handling of the drug body in a significant way. 4. Delayed elimination of the drug in patients with hookworm infection was observed.

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1. The effect of folic acid pretreatment on the experimentally induced convulsions in mice; and on the protection afforded by ethosuximide and phenytoin against these convulsions was investigated. 2. Folic acid per se did not exhibit any convulsant effect 3. Folic acid for three days predisposed, the animals to experimental convulsions and reduced the anticonvulsant activity of ethosuximide and phenytoin.

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