A number of antidiarrhoeal agents were tried in experimental models of diarrhoea viz., castor oil-induced diarrhoea in rats, serotonin-induced diarrhoea in mice, and cholera toxin hypersecretion in rats. The agents, lidamidine. diphenoxylate+atropine. furazolidine, berberine and belladonna were given as pretreatment before the diarrhoea1 challenge, either singly or in various combinations. Lidamidine was most effective among the agents studied.Combinations except for those with lidamidine, offered no additional advantage over single drugs.

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