. Hydrochlorothiazide was investigated for anti-inflammatory action on the exudative and proliferative phases of inflammation The drug exhibited significant anti-inflammatory activity which was not affected by adrenalectomy. Gastric acidity was significantly reduced and there was no evidence of ulceration.

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. Acute toxicity studies of O-ethyl-S, S-diphenyl phosphorodithioate (Hinosan, Bayer 78418), an organophosphate fungicide and insecticide, were conducted on buffalo calves. The effect of hinosancm blood cholinesterase demonstrated that it is an effective inhibitor of cholinesterase activity in vivo Hinosan in single oral doses of 30, 45 and 60 mg/kg resulted in maximal inhibition of blood cholinesterase to the extent of 59.3%, 71.4% and 73.9% respectively after 12-24 h of its administration. The onset of severe toxic symptoms with higher doses (45 and 60 mg/kg) correlated well with the maximum inhibition of cholinesterase activity. The inhibited enzyme recovered slowly after 4 weeks, it returned to 86.5 % and 81.6 % of pretreatment level with 30 and 45 mg/kg doses of hinosan respectively. Hinosan in higher doses viz. 45 and 60 mg/kg increased the SGPT levels while, elevation in levels of SGOT was found with all the doses, suggesting that hinosan can induce internal tissue damage. Hinosan (30 and 45 mg/kg) resulted in gradual rise of SGOT levels which approached its highest at 2nd week and started recovering afterwards but remained significantly elevated 4 weeks after its administration. No change in serum alkaline phosphatase activity was observed.

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. Some new N-substituted aryl sulphonyl-N'ar-alkyl ureas and thioureas were screened for hypoglycaemic activity in rabbits. Their hypoglycaemic pattern resembles tolbutamide and chlorpropamide. The structural relationship, duration of hypoglycaemic action and toxicity are discussed.

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. Analgesic activities of the MAO inhibitor tranylcypromine (TCP) and tricyclic antidepressant imipramine (IMP) were investigated in mice by hot plate, tail clip and bradykinin induced writhing tests. Pretreatment with TCP IO mg/kg i.p. (4h) and IMP 40 mg/kg i.p. (l/2 h) marginally raised the hot plate reaction time but markedly potentiated the morphine analgesia. They also effectively raised the reaction time in the tail clip test. In the bradykinin induced writhing test both TCP and IMP proved to be effective even in l/4 th the doses. When tested for anti-inflammatoty activities in rats TCP 2.5 mg/kg i.p. and IMP 10 mg/kg i.p. inhibited the carrageenin-induced hind paw oedema and in the same doses their daily administration for 7 days inhibited the cotton pellet granuloma.

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. Analysis of the responses elicited by electrical stimulation of the spiral strips prepared from the systemic artery and the abdominal aorta of frogs suggested the presence of cholinergic nerves only. Study of the effects of adrenergic and cholinergic drugs showed the presence of alpha and beta adrenoceptors and atropine sensitive cholinergic receptors

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. Some new N-substituted aryl sulphonyl-N'ar-alkyl ureas and thioureas were screened for hypoglycaemic activity in rabbits. Their hypoglycaemic pattern resembles tolbutamide and chlorpropamide. The structural relationship, duration of hypoglycaemic action and toxicity are discussed.

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. Insertion of a silk thread as intrauterine contraceptive device (IUCD) into one horn of the rat uterus produced hypertrophy, cystic glandular hyperplasia, localized keratinized squamous metaplasia and release of polymorphs in the lumen of IUCD containing horn. These changes were partially prevented by the administration of two nonsteroidal anti-inflammatory drugs, the curcumin (diferuloyl methane, CDRI) and oxyphenbutazone at the dose of 30 mg/kg and 20 mg/kg respectively.

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Both clonidine and apomorphine lowered the open field performance of albino rats. Both when given individually along with antiparkinsonian agents like I-DOPA. benztropine and d -amphetamine lowered the open field scores of these antiparkinsonian agents. The parallel effects of apomorphine and clonidine suggest a common mechanism for their action i.e. stimulation of prarynaptic dopamine and/or norepinephrine receptors in CNS which regulate synthesis and release of DA and/or NE.

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. The effects of intracerebro-ventricularly injected histamine and pretreatment with L-histidine. The precursor of histamine, was studied on the central nervous system of rats. An increase in spontaneous motor activity, reduction of pentobarbitone sleeping time, reduction in the threshold of chemoshock and electric shock seizures was observed with histamine and L-histidine. They were also found to inhibit the ingestive behaviour and exert an analgesic effect on rats.

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