The effects of the decoction of the bark and flower of Albizzia lebbeck were studied for its anti-asthimatic and anti-anaphylactic activity. The decoctions protected the guinea pig against histamine as well as acetylcholine induced broncho-spasm. Chronic treatment with the bark decoction has also protected the sensitized guinea pigs against antigen challenge. However, the drug has no significant effect on the rat mesenteric mast cell count and has not protected the mast cell from the disruption induced by compound 48/80. The drug inhibited the rate of disruption of mast cells induced by antigen in sensitized albino rats. It has no effect on the adrenal. thymus and spleen weight as well as adrenal ascorbic acid but the cholesterol content was significantly reduced. The antiasthmatic and antianaphylactic actvities of the drug cannot be wholly due to smooth muscle relaxant, antihistamine or antispasmodic activity nor are mediated through stability of mast cells or adrenal gland. The effect seems to be due to inhibition of phenomenon of sensitisation.

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The water extract of the stem of Neem Giloe (Tinospora cordifolia), an Indian Indigenous plant, was screened for anti-inflammatory, analgesic and antipyretic actions in albino rats and immunosuppressive effect in albino rabbits. lt significantly inhibited acute inflammatory response evoked by carrageenin in a doss of 50 mg/100 g given orally and intraperitoneally. In chronic inflammation produced by croton-oil in granuloma pouch technique, 20 mg/100 g of the water extract significantly inhibited granulation tissue response; the reduction in exudative response and increase in t he weight of adrenal glands were not significant. A significant inhibition of primary and secondary phases was observed In adjuvant-induced arthritis. It significantly inhibited antibody formation by typhold "H" antigen. A mild analgesic effect of its own as well as potentiation of morphine analgesia were possessed by the extract but it was devoid of antipyretic effect.

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Suxamethonium chloride. a short acting muscle relaxant has been reported to cause prolonged apnoea in some patients. In this study the relationship between pseudo-cholinesterase activity, dibucaine number and duration of apnoea after suxamethonium chloride was investigated in the local population. These patients were otherwise healthy but suffering from minor problems requiring surgical procedures. It may be concluded that estimation of PChE level and dibucaine number is an effective guide for the administration of suxamethonium chloride.

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A series of 10-N-acylamino phenothiazines possessing tertiary butylamino group in their side chain, showed antihistaminic. antispasmodic and antiserotoninergic activity. On comparison with promethazine HCI diphenhydramine HCI and cyproheptadine, the compounds of this series were found feeble in potency but less toxic. All the test compounds were devoid of central nervous system depressant activity.

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Preliminary screening of 8 chemicals was done for antifungal action in vitro against Trichophyton verrucosum, Tricho-phyton mentagrophytes and Trlchophyton simil Griseofulvin. Thiabendazole and organic chlorinated hydrocarbon (Sulfenimide) exhibited uniform antifungal action against all the three test dermatophytes. Chemicals like copper oxychloride, micronised wettable sulphur and kasumin (antibiotic) showed antifungal activity against T. simii in preliminary screening. KOH 0.5% and Formalin 0.5% did not show any antifungal activity against the test dermatophytes. On further study the M.I.C. and M.L.C. of Thiabendarole as fungistatic and fungicidal was 0.312 and 1.25 mg/ml respectively. Similarly in case of Sulfenimide the fungicidal action was present at 0.95% mg/ml.

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The effect of plain insulin was studied in normal mongrel dogs on blood cholesterol level. Intravenous administration of plain insulin in different doses from 0.6 U/kg to 6 U/kg on different groups Of dogs does not cause any significant change in blood cholesterol level over a period extending upto 5 hours. But in a dose of 10 U/kg it causes a significant decrease in blood cholesterol level.

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Promethazine hydrochloride and diphenhydramine hydrochloride, showed a marked and sustained rise in blood pressor in phenobarbitone anaesthetized WLH chickens which is contrary to the effects in mammals. Pressor effect was not blocked by alpha or beta adrenergic receptor blocking agents. Pretreatment with two doses each of alphamethyl-para-tyrosine and reserpine did not affect the pressor effect of antihistamines. However birds pm-treated with higher doses of reserpine (10 mg/kg daily for two days) showed a marked decrease in pressor response to promethazine. The findings suggest that the pressor response to antihistaminics in chicken is probably mediated through the release of catecholamines.

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Seventeen antihistamines were studied far their effect on acetylcholine (Ach) Induced contraction of skeletal muscle (Skm) under Gaddum's superfusion technique. All drugs exhibit some degree of cuare like action In 0.1 to 10 mcg dose except in pheniramine, mabhydroline and metiamide where there was a regression of curarimimetic effect with increasing doses. During recovery from drug effect the tissue showed an increased sensitivity to the action of Ach. In some instances this potentiation was immediate. In high doses (100 mcg and above). some of the antihistamines produced contracture of Skm which was not blocked by curare.

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Intravenous administration of frusemide in rabbit produced hyperglycemia. Administration of 26 mg/kg produced mild, transient non-significant hyperglycemia in normal rabbits but in alloxan treated rabbits marked hyperglycemia of long duration was observed with the same dose. However, in normal rabbit frusemide administered in the dose of 250 mg/kg for 3 consecutive days produced a state resembling clinical diabetes mellitus persisting for one month or even more. The significance of the findings is discussed.

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Penicillin produced a prolonged tall in blood pressure of rats sensitized to it with Freund's adjuvant, fourteen days prior to the experiment. On the other hand. Streptomycin and Oxytetracycline, which are less notorious for causing anaphylactic shock, tailed to produce such an effect. The possibility of using such a test to predict the allergenic potentialities of drugs is discussed.

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Perfusion of rat lung tissue to study the changes in the rate of flow was carried out as a modified version of that described by Tainter, Peddsn and James (1934) and Christine et al. (1976). Bronchoconstrictors decrease the rate of flow and bronchodilators increase this rate. Simulataneously the perfusate can be estimated for mediators of allergy by chemical and biological methods.

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