This study was carried out in order to find out a possible pharmacokinetic explanation for the rate dependent toxicity of turosemide. Twelve cats and eight patients of chronic renal failure were given turosemide intravenously at different rates and doses. Plasma turosemide levels were fluorimetrically estimated in serial blood samples. The elimination curves obtained were studied to get an idea about the compartmental distribution of turosemide when given at different rates and doses. The results provide a possible explanation for the rate dependent ototoxic effect of high doses of turosemide. This study may also provide useful guidelines in deciding the rate of infusion when high doses of furosemide are to be given to patients.

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A number of N1 or N2-substituted-5(2,3,4-,2,4,5-, 2,4,6-and 3,4,5-trimethoxy benzvlidene) hydantoin or 2-thiohy-dantoins have been synthesised and evaluted for their CNS depressant and anticonvulsant activity. A new generic name 'Trimethotoin' is proposed for 2,4,6-trimethoxy benzene derivatives which exhibited potent CNS depressant and anticonvulsant actions.

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Pharmacological effects of the methiodide of the total alkaloid of the leaves of Tiliacora Racemosa on blood pressure, heart and smooth muscles of different animals are described.

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The thrombocytosis promoting effect of aspirinated platelets was studied in six mongrel dogs (recipient group) by injacting aspirinated platelet rich plasma (PRP) from six dogs of the donor grow. Thrombocytosis was observed, with a Peak rise within 24 hours, gradually declining to basal levels around fifth day. Probable mechanism of this effect may be stimulation of thrombopoeisis.

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Administration of adrenaline and cyclic 3'. 5'-adenosine monophosphate to rhesus monkeys caused a significant increase of serum free fatty acids, low density lipoproteins (() and high density lipoproteins (() without any marked change in very low density lipoproteins (pre (). Uptake of acetate-1-C14, into total lipid of lipoprotein fractions was also found to be increased by about two fold in experimental animals. The effect on serum FFA. Lipoproteins and labelled acetate uptake into lipoproteins was found to be more with adrenaline than cyclic AMP. It is likely that initial rise in free fatty acid may be causing a" increase in lipoproteins and further the regulatory role of the hormones on biosynthesis of lipids and enzymes has been discussed.

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Infraperitoneal administration of chlorpromazine in doses of 2.5, 5 and 12.5 mg/kg daily reduces antibody titres against the Salmonella typhi "H" and sheep red cell antigens in rabbits treated from seven days prior to the first immunizing dose. The reduction in the antibodies was found to be dose related. The reduction in antibody titres is not due to hypoproteinemia as serum protein levels were not altered following chlorpromazine administration.

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Full text not available  [PDF]