The ether and alcohol extracts of Luffs echinata. known as Devadali (family cucurbitaceae) offered definite protection against experimentally induced liver injury by Ccl. in albino rats. The ether extract was more effective than the alcohol extract.

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Wild leguminous seed proteins of Cassia marginata, Cassia renigera and Cassia obstusifolia were investigated for their effects on blood and liver cholesterol levels in young albino rats. They were found to have a marked lowering effect on blood and liver cholesterol levels. It is suggested that these effect are probably due to direct or indirect inhibition of cholesterol synthesis in the liver.

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A possible mechanism of the antihyperglycaemic effect of onlon in man is discussed. Probably it affects the metabolism of glucose by reducing the rats of glucogenolysis and neo-glucogenesis in liver.

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The effect of intravenous infusion of 6% calciumchloride on the E. C. G. of sheep, both during and after stopping the administration has been studied. There was significant increase in heart rate at serum calcium levels of 22.35Ort4.365 mg per cent and its intensity increased with the dose. The QT interval and ST segment were shortened significantly while the prolongation of PR interval and QRS complex was insignificant. The amplitudes of R and T waves were increased and it was significant only for the latter at swum calcium levels of 22.350(4.365 to 27.600(5.555 mg %. The infusion of calcium chloride also resulted in various types of arrhythmias viz. sinus arrhythmia with bradycardia and atrio-ventricular blocks.The animals showed laboured respiration and restlessness during infusion and showed tachycardia with disturbed rhythm of premature beats and atrio-ventricular blocks for 2-4 hours after stopping the infusion.There were also delayed deaths.

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The role of brain dopamine in pentylenetetrazol (PTZ) induced clonic convulsions in albino mice was investigated by using drugs which selectively raise brain dopamine levels. dopamine receptor agonists and antagonists.PTZ convulsions were potenliated by drug treatments which selectively increase brain concentrations of dopamine and by dopamine receptor agonists, apomorphine and amphetamine. Haloperidol, a selective dopamine receptor antagonist. inhibited PTZ convulsions and apomorphine or amphetamine induced potentiation of PTZ. The results suggest that dopamine may have a role in PTZ induced clonic convulsions in mice.

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Intravenous magnesium sulphate has been found to be effective in either correcting or preventing the various ventricular arrhythmias and atrial fibrillation, while its effect in atrial flutter is noted to be poor in experimentally induced arrhythmias in dogs.

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The ambulation and rearing activities were tested on 'open field' in rats treated with amphetamine alone and in combination with ( -(-dipyridyl (DDP) and reserpine. The excitatory response of amphetamine in a doss of 2 mg/kg was not observed in rats pretreated with DDP or reserpine. Though the depressed activity in reserpinised rats was significantly antagonised by amphetamine, the values were still lower (P<0.001) than the control values. The data revealed the role of continuous norepinephrine synthesis in amphetamine excitatory response besides its release from the stores. The present work also indicates that dopamine is not directly responsible for amphetamine induced locomotor or stereotyped activity nor doer amphetamine stimulates adrenergic receptors directly to produce the excitatory response.

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Modification of morphine analgesia by pretreatment with sulphapyridine. sulphadiazine. sulphacetamide and sulphamathoxypyridazine has been studied in mice using the tail clip method. The possible role of protein binding in these interactions has been discussed.

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