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May-June 2001
Volume 33 | Issue 3
Page Nos. 145-246
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| EDITORIAL |
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The problems and prospects of plant drug research in india: Pharmacological evaluation of ecotypes in herbal drug development |
p. 145 |
| A Subramoniam |
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| EDUCATIONAL FORUM |
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Genetic polymorphism of CYP2D6 |
p. 147 |
| K. Abraham Benny, C Adithan |
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Current concepts in cannabinoid pharmacology |
p. 170 |
| SK Kulkarni, I Ninan .
Levamisole hydrochloride in low concentration (5 ng/mI) stimulated the movements of the whole worm as well as of the nerve-muscle complex of Setario cervi suspended in an isolated organ bath. At higher concentration (25 ng/mI) the response was biphasic consisting of initial stimulation followed by irreversible paralysis. The initial stimulant effect is not due to release of ACh as it is not blocked by prior addition of d-tubocurarine to the bath fluid. Levamisole in 5 x 25 mg/kg daily dose caused disappearance of microfilariae from the peripheral circulation in 7 of the 8 rats treated: The drug at this dose level had some macrofilaricidal action as well. A higher dose of 5 x 50 mg/kg daily caused complete disappearance of microfilariae from peripheral circulation of all the rats and produced a significant lethal effect on the adult worms The antifilarial efficacy of the drug needs evaluation in domestic animals and men.
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| RESEARCH PAPER |
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Effect of vitamin E, vitamin C and spirulina on the levels of membrane bound enzymes and lipids in some organs of rats exposed to lead |
p. 185 |
| CD Upasani, R Balaraman |
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Sparse sampling approach in rodent toxicokinetic studies to reduce the use of animals |
p. 192 |
| Rani Shubha, Padh Harish |
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Antidepressant augmentation with buspirone: Effects on seizure threshold and brain serotonin levels in mice |
p. 198 |
| Razia Khanam, MAA Siddiqui, KK Pillai, SN Pal |
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| SHORT COMMUNICATION |
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Doxorubicin induced cardiotoxicity and Its modulation by drugs |
p. 203 |
| S Karim, U Bhandari, H Kumar, A Salam, MAA Siddiqui, KK Pillai |
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Anticonvulsant effect of nimodipine alone and in combination with diazepam on PTZ induced status epilepticus |
p. 208 |
| P Khosla, P Pandhi |
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Cholinergic mechanism in imipramine and morphine antinociception |
p. 212 |
| VK Bhargava, Saha Lekha |
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| LETTER |
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Hypoglycaemic effect of the aqueous extract of Boerhavia diffusa leaves  |
p. 215 |
| MA Chude, OE Orisakwe, OJ Afonne, KS Gamaniel, OH Vongtau, E Obi |
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Nimesulide toxicity in dogs |
p. 217 |
| N Ramesh, K Jayakumar, Honnegowda, K Narayana, SK Vijayasarathi |
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Modified method of preparing longitudinal and horizontal rat fundal strips for bioassay |
p. 219 |
| SK Kulkarni, VP Singh, NK Jain |
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Cholinergic mechanism in gabapentin analgesia? |
p. 221 |
| RK Dixit, BhargavaVK |
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Drug prescribing pattern in a tertiary care teaching hospital in Madurai (Tamilnadu) |
p. 223 |
| S Kanakambal, N Murugesh, M Shanthi |
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Oral supplementation of zinc promotes erythrocyte superoxide dismutase activity in chronic cigarette smokers: Report on a pilot clinical trial |
p. 224 |
| KN Sulochana, R Punitham, S Ramakrishnan |
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Possible regulatory role of dynorphin (1-13) in stress-induced gastric ulcerogenesis |
p. 225 |
| KK Sharma, PK Mediratta |
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| CORRESPONDENCE |
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Role of nitric oxide in cocaine-and amphetamine-induced increased locomotor activity and reverse tolerance |
p. 227 |
| Sangraula Himal, Jain Atul, KK Sharma |
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| MOLECULES OF THE MILLENNIUM |
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Antiepileptic drugs |
p. 229 |
| R Balaraman |
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| WEB WISE |
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Indiacancer.org |
p. 231 |
| Singh Jatinder |
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| BOOK REVIEW |
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A short textbook of professional medical ethics |
p. 233 |
| GN Prabhakaran |
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| CALENDAR REVIEW |
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Calendar for Pharmacist 2001 |
p. 234 |
| DG Shewade |
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| CONFERENCE ABSTRACTS |
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Abstracts of research papers presented in the Annual conference of the Indian Pharmacological Society, Gandhinagar, December 28-30, 2000-Part-III |
p. 235 |
| IPS |
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