1. Blood pressures by a tail plethysmographic method without anaesthesia and pain sensitivity over a range of temperatures using both the tail flick and hot plate methods in male spontaneously hypertensive rats (SHR), normotensive Wistar-Kyoto (WK) two kidney, one clip renovascular Sprague-Dawley rats (SDLRAS) and sham-operated Sprague-Dawley rats (SDSHAM) were recorded. 2. Latency to paw lick or jump was greater in SHR than any other group at 54oC This longer latency correlated significantly and positively with tail blood pressure. 3. It therefore seems that genetic factors, blood pressure and pain sensitivity may be related.

1. The levels of deoxyribonuclic acid (DNA), ribonucleic acid (RNA) and total proteins in blood, aqueous humor, lens and electrolytes and water content in lens of normal as well as alloxan-treated rats have been determined. 2. A decrease in the levels of DNA, RNA and total proteins were observed in blood, aqueous humor and lenses obtained from rats pretreated with alloxan. Although, the average concentrations of DNA, RNA and total proteins in aqueous humor is higher than in the blood. 3. In contrast to normal lenses, alloxan-induced, cataractous lenses showed an increase in sodium, calcium, water content and a fall in potassium content. 4. Role of DNA, RNA, total proteins, electrolytes and water in normal lens and its reduction or change in cataractous condition has been discussed.

1. The aqueous extract of the leaf of Kalanchoe integra (KI) produced CNS depressant effect. It affected forced co-ordinated motor activity, decreased the spontaneous motor activity, increased pentoobarbitone sleeping time and impaired conditioned avoidance response. 2. It produced marked hypotensive effect in anaesthetised dog, which was not blocked by either atropine or promethazine and negative inotropic effect on intact dog heart which probably was responsible for the hypotensive action. 3. KI produced dose-dependent inhibition of the contractions induced by acetylcholine, histamine and barium on guinea pig ileum and was devoid of any effect on the frog rectus abdominis muscle. 4. A positive inotrpic effect was observed on isolated frog heart which was not blocked by either propranolol or promethazine.

1. Aqueous extract of canavalia virosa (CV) was evaluated for its pharmacological effects in various experimental animals. 2. The extract produced a number of CNS effects including potentiation of pentobarbitone hypnosis in mice at (1 mg 100g); potentiation of morphine catalepsy in albino rats (1 mg/100g) C.V. did not have any behavioural effects in terms of its effects on rota-rod test or exploratory behaviour in mice. 3. C.V. markedly degranulated mesenteric mast leading to liberation of histamine which may possibly be responsible for hypotension and gestrointestinal symptoms seen in poisoning due to ingestion of seeds of C.V.

1. The compound 3-methyl-5-phenyl-(4'methyl)-quinolenodiazepine, a newly synthe-sised molecule combines a quinolene ring with diazepine heterocyclic ring, both reportedly having CNS depressant properties, was investigated in the present study for CNS activity in rats and mice. 2. The compound possesses weak anxiolytic properties, weak appetite suppressant properties and mild central muscle relaxant properties. These effects occur at a dose which does not reduce spontaneous motor activity or cause sedation/hypnosis. 3. The LD50 of the compound is 250 ( 18.97 mg.kg-1.

1. Evidence has collected that neurohumors play a significant role in regulating the worm movements. Addition of acetylcholine, 5-HT, histamine or adrenaline to larval suspension caused initial increase in the motility of the larvae followed by paralysis. 2. The onset of action was immediate following addition of 5-HT, histamine and adrenaline. However, the effect of Ach was after a latent period. 3. The effect of 5-HT, histamine and adrenaline appear to be only depressent caused by hyperpolarization of the nerve-muscle complex and the initial stimulation could be due to the irritant effect of these chemicals. 4. The spastic paralysis caused by Ach indicate that the drug causes deplorization at the neuromuscular junction. 5. All the four neurohumoral agents caused concentration related inhibition of the transverse migration of the infective larvae through soil particles.

1. Plasma levels of ethinylestradiol (EE) were studied in normal healthy females, who were either fast, intermediate or slow oxidizers of debrisoquine. 2. No statistically significant correlation was found between Area Under Curve (AUC) and maximum levels (CMax) of EE in different oxidation phenotypes. 3. It is concluded that slow oxidizers are not at greater risk of concentration-dependent toxicity of EE.

1. In the present study we found that monocrotophos was highly toxic to chicks and least toxic to fish when compared with rats. 2. Methyl benzimidazole carbamate was moderately toxic to fish with practically no toxicity to rats. 3. These pesticides were more toxic to rats when administered orally than percutaneously.

1. Plasma prostaglandin levels were estimated in 13 normal individuals and in 35 patients suffering from febrile illnesses due to short viral fever, viral hepatitis, amoebic liver abscess, transfusion reaction, lobar pneumonia, enteric fever, acute malarial fever and pulmonary tuberculosis. 2. In all cases of febrile illnesses there was 2-5 fold increase in plasma prostaglandin levels which again came down to normal after oral administration of paracetamol or when the fever subsided itself. 3. The findings suggest that there is increased synthesis/release of prostaglandins in the blood which crosses the blood brain barrier to act upon the pre-optic anterior hypothalamus to produce fever.